The pluripotent state in mouse and human

Kathryn C. Davidson, Elizabeth A. Mason, Martin F. Pera

Research output: Contribution to journalReview ArticleResearchpeer-review

91 Citations (Scopus)

Abstract

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture equivalent of the late epiblast in the preimplantation embryo, with which they share a unique defining set of features. Recent studies have focused on the identification and propagation of a similar cell state in human. Although the capture of an exact human equivalent of the mouse naïve PSC remains an elusive goal, comparative studies spurred on by this quest are lighting the path to a deeper understanding of pluripotent state regulation in early mammalian development.

Original languageEnglish
Pages (from-to)3090-3099
Number of pages10
JournalDevelopment
Volume142
Issue number18
DOIs
Publication statusPublished - 23 Sep 2015
Externally publishedYes

Keywords

  • Human
  • Mouse
  • Pluripotent state

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