The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair

Sebastian Dworkin, Stephen Jane, Charbel Darido

Research output: Contribution to journalArticleOther

20 Citations (Scopus)


The planar cell polarity (PCP) pathway plays a critical role in diverse developmental processes that require coordinated cellular movement, including neural tube closure and renal tubulogenesis. Recent studies have demonstrated that this pathway also has emerging relevance to the epidermis, as PCP signaling underpins many aspects of skin biology and pathology, including epidermal development, hair orientation, stem cell division and cancer. Coordinated cellular movement required for epidermal repair in mammals is also regulated by PCP signaling, and in this context, a new PCP gene encoding the developmental transcription factor Grainyhead-like 3 (Grhl3) is critical. This review focuses on the role that PCP signaling plays in the skin across a variety of epidermal functions and highlights perturbations that induce epidermal pathologies.
Original languageEnglish
Pages (from-to)202 - 208
Number of pages7
Issue number3
Publication statusPublished - 2011

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