The placental transfer of betamethasone

Marisa C. Petersen, R. L. Nation, J. J. Ashley, W. G. McBride

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Abstract

The plasma concentrations of beta-methasone in a maternal peripheral vein (mv) and in the umbilical vein (uv) were measured at delivery in eleven patients after the administration of beta-methasone phosphate equivalent to 8 mg betamethasone. Betamethasone concentrations were measured in plasma using a specific and sensitive HPLC assay. The time interval between the last dose and delivery ranged from 56 min to 800 min and over this time period the mean plasma concentration ratioCuv/Cmv was 0.28±0.04 (SD) and exhibited no time dependence.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume18
Issue number3
DOIs
Publication statusPublished - 1 May 1980
Externally publishedYes

Keywords

  • betamethasone
  • HPLC assay
  • placental transfer
  • plasma concentrations
  • pregnancy

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