The pKa Distribution of Drugs: Application to Drug Discovery

David Thomas Manallack

Research output: Contribution to journalArticleResearchpeer-review


The acid-base dissociation constant (pKa) of a drug is a key physicochemical parameter influencing many biopharmaceutical characteristics. While this has been well established, the overall proportion of non-ionizable and ionisable compounds for drug-like substances is not well known. Even less well known is the overall distribution of acid and base pKa values. The current study has reviewed the literature with regard to both the proportion of ionizable substances and pKa distributions.
Original languageEnglish
Pages (from-to)25 - 38
Number of pages14
JournalPerspectives in Medicinal Chemistry
Issue number1
Publication statusPublished - 2007

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