The phylogenomics of Shigella spp.

Kate S. Baker; Jane Hawkey; Danielle Ingle; Sydney L. Miles; Hao Chung The

doi:10.1016/B978-0-323-99886-4.00020-X

The phylogenomics of Shigella spp.

Kate S. Baker, Jane Hawkey, Danielle Ingle, Sydney L. Miles, Hao Chung The

Infectious Diseases

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

Shigella spp. are genomically and immunologically diverse, specialized pathovars of Escherichia coli that are taxonomically separated owing to their comparatively high disease burden and distinctive genomic subtypes and genetic features. Pathogenicity islands on their 4.3–4.9Mbp genome and their large (>126kbp) invasion plasssmid (pINV),1 which they share with enteroinvasive E. coli (EIEC, see the second Section), encode the machinery required to invade colonic epithelial cells and manifest the severe diarrheal disease shigellosis (previously known as bacillary dysentery).

Original language	English
Title of host publication	Phylogenomics
Subtitle of host publication	Foundations, Methods, and Pathogen Analysis
Editors	Igor Mokrousov, Egor Shitikov
Place of Publication	London UK
Publisher	Elsevier - Mosby
Chapter	12
Pages	283-304
Number of pages	22
Edition	1st
ISBN (Electronic)	9780323998864
ISBN (Print)	9780323913096
DOIs	https://doi.org/10.1016/B978-0-323-99886-4.00020-X
Publication status	Published - 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antimicrobial resistance
genomics
phylogenomics
Shigella
virulence

Access to Document

10.1016/B978-0-323-99886-4.00020-X

Cite this

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title = "The phylogenomics of Shigella spp.",

abstract = "Shigella spp. are genomically and immunologically diverse, specialized pathovars of Escherichia coli that are taxonomically separated owing to their comparatively high disease burden and distinctive genomic subtypes and genetic features. Pathogenicity islands on their 4.3–4.9Mbp genome and their large (>126kbp) invasion plasssmid (pINV),1 which they share with enteroinvasive E. coli (EIEC, see the second Section), encode the machinery required to invade colonic epithelial cells and manifest the severe diarrheal disease shigellosis (previously known as bacillary dysentery).",

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language = "English",

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T1 - The phylogenomics of Shigella spp.

AU - Baker, Kate S.

AU - Hawkey, Jane

AU - Ingle, Danielle

AU - Miles, Sydney L.

AU - The, Hao Chung

PY - 2024

Y1 - 2024

N2 - Shigella spp. are genomically and immunologically diverse, specialized pathovars of Escherichia coli that are taxonomically separated owing to their comparatively high disease burden and distinctive genomic subtypes and genetic features. Pathogenicity islands on their 4.3–4.9Mbp genome and their large (>126kbp) invasion plasssmid (pINV),1 which they share with enteroinvasive E. coli (EIEC, see the second Section), encode the machinery required to invade colonic epithelial cells and manifest the severe diarrheal disease shigellosis (previously known as bacillary dysentery).

AB - Shigella spp. are genomically and immunologically diverse, specialized pathovars of Escherichia coli that are taxonomically separated owing to their comparatively high disease burden and distinctive genomic subtypes and genetic features. Pathogenicity islands on their 4.3–4.9Mbp genome and their large (>126kbp) invasion plasssmid (pINV),1 which they share with enteroinvasive E. coli (EIEC, see the second Section), encode the machinery required to invade colonic epithelial cells and manifest the severe diarrheal disease shigellosis (previously known as bacillary dysentery).

KW - antimicrobial resistance

KW - genomics

KW - phylogenomics

KW - Shigella

KW - virulence

UR - https://www.scopus.com/pages/publications/85199089755

U2 - 10.1016/B978-0-323-99886-4.00020-X

DO - 10.1016/B978-0-323-99886-4.00020-X

M3 - Chapter (Book)

AN - SCOPUS:85199089755

SN - 9780323913096

SP - 283

EP - 304

BT - Phylogenomics

A2 - Mokrousov, Igor

A2 - Shitikov, Egor

PB - Elsevier - Mosby

CY - London UK

ER -

The phylogenomics of Shigella spp.

Abstract

UN SDGs

Keywords

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