The pharmacokinetics of chlormethiazole following intravenous administration in the aged

R. L. Nation, B. Learoyd, J. Barber, E. J. Triggs

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Eight healthy aged subjects were administered 1.2 g of chlormethiazole by constant-rate intravenous infusion. The disposition of the drug was found to be multi-exponential in character. Fits of plasma level-time data to two- and three-compartment open models were assessed with the aid of statistical tests. For three of the subjects the experimental data were adequately fitted to a two-compartment pharmacokinetic model, however a three-compartment model was necessary to fit the data observed for a further four subjects. An anomalous chlormethiazole plasma concentration-time curve was obtained for the remaining subject. The disposition half-life of chlormethiazole was 8.49±3.28 h and the plasma clearance was 16.14±5.00 ml/min/kg. These values were significantly different to those reported earlier for young adult subjects and the clinical implications have been discussed. The blood/plasma concentration ratio of chlormethiazole was found to be approximately one with some evidence for concentration dependence.

Original languageEnglish
Pages (from-to)407-415
Number of pages9
JournalEuropean Journal of Clinical Pharmacology
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Nov 1976

Keywords

  • blood/plasma concentration ratio
  • Chlormethiazole pharmacokinetics
  • disposition half-life
  • elderly human subjects
  • plasma clearance

Cite this

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abstract = "Eight healthy aged subjects were administered 1.2 g of chlormethiazole by constant-rate intravenous infusion. The disposition of the drug was found to be multi-exponential in character. Fits of plasma level-time data to two- and three-compartment open models were assessed with the aid of statistical tests. For three of the subjects the experimental data were adequately fitted to a two-compartment pharmacokinetic model, however a three-compartment model was necessary to fit the data observed for a further four subjects. An anomalous chlormethiazole plasma concentration-time curve was obtained for the remaining subject. The disposition half-life of chlormethiazole was 8.49±3.28 h and the plasma clearance was 16.14±5.00 ml/min/kg. These values were significantly different to those reported earlier for young adult subjects and the clinical implications have been discussed. The blood/plasma concentration ratio of chlormethiazole was found to be approximately one with some evidence for concentration dependence.",
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The pharmacokinetics of chlormethiazole following intravenous administration in the aged. / Nation, R. L.; Learoyd, B.; Barber, J.; Triggs, E. J.

In: European Journal of Clinical Pharmacology, Vol. 10, No. 6, 01.11.1976, p. 407-415.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Nation, R. L.

AU - Learoyd, B.

AU - Barber, J.

AU - Triggs, E. J.

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N2 - Eight healthy aged subjects were administered 1.2 g of chlormethiazole by constant-rate intravenous infusion. The disposition of the drug was found to be multi-exponential in character. Fits of plasma level-time data to two- and three-compartment open models were assessed with the aid of statistical tests. For three of the subjects the experimental data were adequately fitted to a two-compartment pharmacokinetic model, however a three-compartment model was necessary to fit the data observed for a further four subjects. An anomalous chlormethiazole plasma concentration-time curve was obtained for the remaining subject. The disposition half-life of chlormethiazole was 8.49±3.28 h and the plasma clearance was 16.14±5.00 ml/min/kg. These values were significantly different to those reported earlier for young adult subjects and the clinical implications have been discussed. The blood/plasma concentration ratio of chlormethiazole was found to be approximately one with some evidence for concentration dependence.

AB - Eight healthy aged subjects were administered 1.2 g of chlormethiazole by constant-rate intravenous infusion. The disposition of the drug was found to be multi-exponential in character. Fits of plasma level-time data to two- and three-compartment open models were assessed with the aid of statistical tests. For three of the subjects the experimental data were adequately fitted to a two-compartment pharmacokinetic model, however a three-compartment model was necessary to fit the data observed for a further four subjects. An anomalous chlormethiazole plasma concentration-time curve was obtained for the remaining subject. The disposition half-life of chlormethiazole was 8.49±3.28 h and the plasma clearance was 16.14±5.00 ml/min/kg. These values were significantly different to those reported earlier for young adult subjects and the clinical implications have been discussed. The blood/plasma concentration ratio of chlormethiazole was found to be approximately one with some evidence for concentration dependence.

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