The pathogenesis of liver disease in the setting of HIV-hepatitis B virus coinfection

David M. Iser, Sharon R. Lewin

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)


There are many potential reasons for increased liver-related mortality in HIV-hepatitis B virus (HBV) coinfection compared with either infection alone. HIV infects multiple cells in the liver and might potentially alter the life cycle of HBV, although evidence to date is limited. Unique mutations in HBV have been defined in HIV-HBV-coinfected individuals and might directly alter pathogenesis. In addition, an impaired HBV-specific T-cell immune response is likely to be important. The roles of microbial translocation, immune activation and increased hepatic stellate cell activation will be important areas for future study.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalAntiviral Therapy
Issue number2
Publication statusPublished - 2009
Externally publishedYes

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