The p53-Mdm2 loop: A critical juncture of stress response

Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt, Ygal Haupt

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

24 Citations (Scopus)

Abstract

The presence of a functional p53 protein is a key factor for the proper suppression of cancer development. A loss of p53 activity, by mutations or inhibition, is often associated with human malignancies. The p53 protein integrates various stress signals into a growth restrictive cellular response. In this way, p53 eliminates cells with a potential to become cancerous. Being a powerful decision maker, it is imperative that p53 will be activated properly, efficiently and temporarily in response to stress. Equally important is that p53 activation will be extinguished upon recovery from stress, and that improper activation of p53 will be avoided. Failure to achieve these aims is likely to have catastrophic consequences for the organism. The machinery that governs this tight regulation is largely based on the major inhibitor of p53, Mdm2, which both blocks p53 activities and promotes its destabilization. The interplay between p53 and Mdm2 involves a complex network of positive and negative feedback loops. Relief from Mdm2 suppression is required for p53 to be stabilized and activated in response to stress. Protection from Mdm2 entails a concerted action of modifying enzymes and partner proteins. The association of p53 with the PML-nuclear bodies may provide an infrastructure in which this complex regulatory network can be orchestrated. In this chapter we use examples to illustrate the regulatory machinery that drives this network.

Original languageEnglish
Title of host publicationMutant p53 and MDM2 in Cancer
EditorsSwati Palit Deb, Sumitra Deb
Place of PublicationDordrecht
PublisherSpringer
Chapter9
Pages161-186
Number of pages26
ISBN (Electronic)9789401792110
ISBN (Print)9789401792103
DOIs
Publication statusPublished - 2014
Externally publishedYes

Publication series

NameJournal of Cellular Biochemistry
PublisherWiley-Blackwell
ISSN (Print)0306-0225

Keywords

  • c-Abl
  • Chk
  • Degradation
  • Mdm2 (Hdm2)
  • Nuclear export
  • p53
  • Phosphorylation
  • PML nuclear bodies
  • Ubiquitination

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