The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects againts apoptosis

Anissa Jabbour, Paul G Ekert, Melissa Knight, David M Ashley, E J Coulson, Christine J Hawkins

Research output: Contribution to journalShort ReviewOtherpeer-review

44 Citations (Scopus)

Abstract

This study characterized the ability of a new member of the p35 family, p49, to inhibit a number of mammalian and insect caspases. p49 blocked apoptosis triggered by treatment with Fas ligand (FasL), Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or ultraviolet (UV) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin. The caspase cleavage site in p49 was determined, and mutation of the P1 residue of this site abolished the ability of p49 to inhibit caspases, implying that p49 inhibits caspases through an analogous suicide-substrate mechanism to p35. Unlike p35, p49 inhibited the upstream insect caspase DRONC.
Original languageEnglish
Pages (from-to)1311 - 1320
Number of pages10
JournalCell Death and Differentiation
Volume9
Issue number12
DOIs
Publication statusPublished - 2002
Externally publishedYes

Cite this