The oyster genome reveals stress adaptation and complexity of shell formation

Jun Wang, Guofan Zhang, Xiaodong Fang, Ximing Guo, Li Li, Ruibang Luo, Fei Xu, Pengcheng Yang, Linlin Zhang, Xiaotong Wang, Haigang Qi, Zhiqiang Xiong, Huayong Que, Yinlong Xie, Peter W.H. Holland, Jordi Paps, Yabing Zhu, Fucun Wu, Yuanxin Chen, Jiafeng WangChunfang Peng, Jie Meng, Lan Yang, Jun Liu, Bo Wen, Na Zhang, Zhiyong Huang, Qihui Zhu, Yue Feng, Andrew Mount, Dennis Hedgecock, Zhe Xu, Yunjie Liu, Tomislav Domazet-Lošo, Yishuai Du, Xiaoqing Sun, Shoudu Zhang, Binghang Liu, Peizhou Cheng, Xuanting Jiang, Juan Li, Dingding Fan, Wei Wang, Wenjing Fu, Tong Wang, Bo Wang, Jibiao Zhang, Zhiyu Peng, Yingxiang Li, Na Li, Jinpeng Wang, Maoshan Chen, Yan He, Fengji Tan, Xiaorui Song, Qiumei Zheng, Ronglian Huang, Hailong Yang, Xuedi Du, Li Chen, Mei Yang, Patrick M. Gaffney, Shan Wang, Longhai Luo, Zhicai She, Yao Ming, Wen Huang, Shu Zhang, Baoyu Huang, Yong Zhang, Tao Qu, Peixiang Ni, Guoying Miao, Junyi Wang, Qiang Wang, Christian E.W. Steinberg, Haiyan Wang, Ning Li, Lumin Qian, Guojie Zhang, Yingrui Li, Huanming Yang, Xiao Liu, Ye Yin, Jian Wang

Research output: Contribution to journalArticleResearchpeer-review

1345 Citations (Scopus)

Abstract

The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is highly polymorphic and rich in repetitive sequences, with some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set of genes responding to environmental stress. The expansion of genes coding for heat shock protein 70 and inhibitors of apoptosis is probably central to the oyster's adaptation to sessile life in the highly stressful intertidal zone. Our analyses also show that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. The oyster genome sequence fills a void in our understanding of the Lophotrochozoa.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalNature
Volume490
Issue number7418
DOIs
Publication statusPublished - 4 Oct 2012
Externally publishedYes

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