The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies

Michael Haase, Prasad V Devarajan, Anja Haase-Fielitz, Rinaldo Bellomo, Dinna N Cruz, Gebhard Wagener, Catherine Dent Krawczeski, Jay L Koyner, Patrick Murray, Michael Zappitelli, Stuart L Goldstein, Konstantinos Makris, Claudio Ronco, Johannes Karl Martensson, Claes-Roland Martling, Per Venge, Edward Siew, Lorraine B Ware, Talat Alp Ikizler, Peter Rene Mertens

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Abstract

The aim of this study was to test the hypothesis that, without diagnostic changes in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels identify patients with subclinical acute kidney injury (AKI) and therefore worse prognosis. Background: Neutrophil gelatinase-associated lipocalin detects subclinical AKI hours to days before increases in serum creatinine indicate manifest loss of renal function. Methods: We analyzed pooled data from 2,322 critically ill patients with predominantly cardiorenal syndrome from 10 prospective observational studies of NGAL. We used the terms NGAL(-) or NGAL(+) according to study-specific NGAL cutoff for optimal AKI prediction and the terms sCREA(-) or sCREA(+) according to consensus diagnostic increases in serum creatinine defining AKI. A priori-defined outcomes included need for renal replacement therapy (primary endpoint), hospital mortality, their combination, and duration of stay in intensive care and in-hospital.
Original languageEnglish
Pages (from-to)1752 - 1761
Number of pages10
JournalJournal of the American College of Cardiology
Volume57
Issue number17
DOIs
Publication statusPublished - 2011
Externally publishedYes

Cite this

Haase, Michael ; Devarajan, Prasad V ; Haase-Fielitz, Anja ; Bellomo, Rinaldo ; Cruz, Dinna N ; Wagener, Gebhard ; Krawczeski, Catherine Dent ; Koyner, Jay L ; Murray, Patrick ; Zappitelli, Michael ; Goldstein, Stuart L ; Makris, Konstantinos ; Ronco, Claudio ; Martensson, Johannes Karl ; Martling, Claes-Roland ; Venge, Per ; Siew, Edward ; Ware, Lorraine B ; Ikizler, Talat Alp ; Mertens, Peter Rene. / The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. In: Journal of the American College of Cardiology. 2011 ; Vol. 57, No. 17. pp. 1752 - 1761.
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title = "The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies",
abstract = "The aim of this study was to test the hypothesis that, without diagnostic changes in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels identify patients with subclinical acute kidney injury (AKI) and therefore worse prognosis. Background: Neutrophil gelatinase-associated lipocalin detects subclinical AKI hours to days before increases in serum creatinine indicate manifest loss of renal function. Methods: We analyzed pooled data from 2,322 critically ill patients with predominantly cardiorenal syndrome from 10 prospective observational studies of NGAL. We used the terms NGAL(-) or NGAL(+) according to study-specific NGAL cutoff for optimal AKI prediction and the terms sCREA(-) or sCREA(+) according to consensus diagnostic increases in serum creatinine defining AKI. A priori-defined outcomes included need for renal replacement therapy (primary endpoint), hospital mortality, their combination, and duration of stay in intensive care and in-hospital.",
author = "Michael Haase and Devarajan, {Prasad V} and Anja Haase-Fielitz and Rinaldo Bellomo and Cruz, {Dinna N} and Gebhard Wagener and Krawczeski, {Catherine Dent} and Koyner, {Jay L} and Patrick Murray and Michael Zappitelli and Goldstein, {Stuart L} and Konstantinos Makris and Claudio Ronco and Martensson, {Johannes Karl} and Claes-Roland Martling and Per Venge and Edward Siew and Ware, {Lorraine B} and Ikizler, {Talat Alp} and Mertens, {Peter Rene}",
year = "2011",
doi = "10.1016/j.jacc.2010.11.051",
language = "English",
volume = "57",
pages = "1752 -- 1761",
journal = "Journal of the American College of Cardiology",
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Haase, M, Devarajan, PV, Haase-Fielitz, A, Bellomo, R, Cruz, DN, Wagener, G, Krawczeski, CD, Koyner, JL, Murray, P, Zappitelli, M, Goldstein, SL, Makris, K, Ronco, C, Martensson, JK, Martling, C-R, Venge, P, Siew, E, Ware, LB, Ikizler, TA & Mertens, PR 2011, 'The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies', Journal of the American College of Cardiology, vol. 57, no. 17, pp. 1752 - 1761. https://doi.org/10.1016/j.jacc.2010.11.051

The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. / Haase, Michael; Devarajan, Prasad V; Haase-Fielitz, Anja; Bellomo, Rinaldo; Cruz, Dinna N; Wagener, Gebhard; Krawczeski, Catherine Dent; Koyner, Jay L; Murray, Patrick; Zappitelli, Michael; Goldstein, Stuart L; Makris, Konstantinos; Ronco, Claudio; Martensson, Johannes Karl; Martling, Claes-Roland; Venge, Per; Siew, Edward; Ware, Lorraine B; Ikizler, Talat Alp; Mertens, Peter Rene.

In: Journal of the American College of Cardiology, Vol. 57, No. 17, 2011, p. 1752 - 1761.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies

AU - Haase, Michael

AU - Devarajan, Prasad V

AU - Haase-Fielitz, Anja

AU - Bellomo, Rinaldo

AU - Cruz, Dinna N

AU - Wagener, Gebhard

AU - Krawczeski, Catherine Dent

AU - Koyner, Jay L

AU - Murray, Patrick

AU - Zappitelli, Michael

AU - Goldstein, Stuart L

AU - Makris, Konstantinos

AU - Ronco, Claudio

AU - Martensson, Johannes Karl

AU - Martling, Claes-Roland

AU - Venge, Per

AU - Siew, Edward

AU - Ware, Lorraine B

AU - Ikizler, Talat Alp

AU - Mertens, Peter Rene

PY - 2011

Y1 - 2011

N2 - The aim of this study was to test the hypothesis that, without diagnostic changes in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels identify patients with subclinical acute kidney injury (AKI) and therefore worse prognosis. Background: Neutrophil gelatinase-associated lipocalin detects subclinical AKI hours to days before increases in serum creatinine indicate manifest loss of renal function. Methods: We analyzed pooled data from 2,322 critically ill patients with predominantly cardiorenal syndrome from 10 prospective observational studies of NGAL. We used the terms NGAL(-) or NGAL(+) according to study-specific NGAL cutoff for optimal AKI prediction and the terms sCREA(-) or sCREA(+) according to consensus diagnostic increases in serum creatinine defining AKI. A priori-defined outcomes included need for renal replacement therapy (primary endpoint), hospital mortality, their combination, and duration of stay in intensive care and in-hospital.

AB - The aim of this study was to test the hypothesis that, without diagnostic changes in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels identify patients with subclinical acute kidney injury (AKI) and therefore worse prognosis. Background: Neutrophil gelatinase-associated lipocalin detects subclinical AKI hours to days before increases in serum creatinine indicate manifest loss of renal function. Methods: We analyzed pooled data from 2,322 critically ill patients with predominantly cardiorenal syndrome from 10 prospective observational studies of NGAL. We used the terms NGAL(-) or NGAL(+) according to study-specific NGAL cutoff for optimal AKI prediction and the terms sCREA(-) or sCREA(+) according to consensus diagnostic increases in serum creatinine defining AKI. A priori-defined outcomes included need for renal replacement therapy (primary endpoint), hospital mortality, their combination, and duration of stay in intensive care and in-hospital.

UR - http://www.sciencedirect.com/science/article/pii/S0735109711005754

U2 - 10.1016/j.jacc.2010.11.051

DO - 10.1016/j.jacc.2010.11.051

M3 - Article

VL - 57

SP - 1752

EP - 1761

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 17

ER -