The nitric oxide system in glucocorticoid-induced hypertension

Judith A. Whitworth, Christopher G. Schyvens, Yi Zhang, Miles C. Andrews, George J. Mangos, John J. Kelly

Research output: Contribution to journalReview ArticleResearchpeer-review

73 Citations (Scopus)


The blood pressure-raising effects of adrenocortical steroids with predominantly glucocorticoid activity, both naturally occurring and synthetic, are well known. Recent evidence suggests that the nitric oxide system plays a key role in the hypertension produced by glucocorticoids. Glucocorticoid actions at various sites in the nitric oxide synthase (NOS) pathway may result in elevated blood pressure. These include: alterations in L-arginine availability or transport; NOS2 and NOS3 downregulation; reduced cofactor bioavailability; NOS uncoupling; a concomitant elevation in reactive oxygen species and removal of nitric oxide (NO) from the vascular environment; alterations in whole body antioxidant status; and erythropoietin induced resistance to NO.

Original languageEnglish
Pages (from-to)1035-1043
Number of pages9
JournalJournal of Hypertension
Issue number6
Publication statusPublished - 1 Jun 2002
Externally publishedYes


  • Adrenocorticotrophic hormone
  • Animal
  • Cortisol
  • Glucocorticoid-induced hypertension
  • Human
  • Hypertension
  • Nitric oxide

Cite this