TY - JOUR
T1 - The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness
AU - Dautov, Rustem
AU - Ngo, Doan
AU - Licari, G
AU - Liu, S
AU - Sverdlov, Aaron L
AU - Ritchie, Rebecca H
AU - Harper, Barbara Kathryn
AU - Horowitz, John David
AU - Chirkov, Yuliy Y
PY - 2013
Y1 - 2013
N2 - Impaired platelet responsiveness to nitric oxide (NO resistance) is a common characteristic of many cardiovascular disease states and represents an independent risk factor for cardiac events and mortality. NO resistance reflects both scavenging of NO by superoxide (O2-), and impairment of the NO receptor, soluble guanylate cyclase (sGC). There is thus an urgent need for circumvention of NO resistance in order to improve clinical outcomes. Nitroxyl (HNO), like NO, produces vasodilator and anti-aggregatory effects, largely via sGC activation, but is not inactivated by O2-. We tested the hypothesis that HNO circumvents NO resistance in human platelets. In 57 subjects with or without ischemic heart disease, platelet responses to the HNO donor isopropylamine NONOate (IPA/NO) and the NO donor sodium nitroprusside (SNP) were compared. While SNP (10muM) induced 29+/-3 (p
AB - Impaired platelet responsiveness to nitric oxide (NO resistance) is a common characteristic of many cardiovascular disease states and represents an independent risk factor for cardiac events and mortality. NO resistance reflects both scavenging of NO by superoxide (O2-), and impairment of the NO receptor, soluble guanylate cyclase (sGC). There is thus an urgent need for circumvention of NO resistance in order to improve clinical outcomes. Nitroxyl (HNO), like NO, produces vasodilator and anti-aggregatory effects, largely via sGC activation, but is not inactivated by O2-. We tested the hypothesis that HNO circumvents NO resistance in human platelets. In 57 subjects with or without ischemic heart disease, platelet responses to the HNO donor isopropylamine NONOate (IPA/NO) and the NO donor sodium nitroprusside (SNP) were compared. While SNP (10muM) induced 29+/-3 (p
UR - http://www.sciencedirect.com/science/article/pii/S1089860313003133
U2 - 10.1016/j.niox.2013.08.006
DO - 10.1016/j.niox.2013.08.006
M3 - Article
SN - 1089-8603
VL - 35
SP - 72
EP - 78
JO - Nitric Oxide-Biology and Chemistry
JF - Nitric Oxide-Biology and Chemistry
ER -
