Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 692 - 706 |
| Number of pages | 15 |
| Journal | EMBO Journal |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 |
Cite this
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The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. / Gugasyan, Raffi; Horat, Elisha; Kinkel, Sarah; Ross, Fiona; Grigoriadis, George; Gray, Daniel; O'Keeffe, Meredith; Berzins, Stuart; Belz, Gabrielle; Grumont, Raelene; Banerjee, Ashish; Strasser, Andreas; Godfrey, Dale; Tsichlis, Philip; Gerondakis, Steven.
In: EMBO Journal, Vol. 31, No. 3, 2012, p. 692 - 706.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties
AU - Gugasyan, Raffi
AU - Horat, Elisha
AU - Kinkel, Sarah
AU - Ross, Fiona
AU - Grigoriadis, George
AU - Gray, Daniel
AU - O'Keeffe, Meredith
AU - Berzins, Stuart
AU - Belz, Gabrielle
AU - Grumont, Raelene
AU - Banerjee, Ashish
AU - Strasser, Andreas
AU - Godfrey, Dale
AU - Tsichlis, Philip
AU - Gerondakis, Steven
PY - 2012
Y1 - 2012
N2 - The role of specific members of the NF-I?B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-I?B1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF + thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-I?B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8 + thymocytes with memory cell characteristics. A? 2012 European Molecular Biology Organization All Rights Reserved.
AB - The role of specific members of the NF-I?B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-I?B1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF + thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-I?B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8 + thymocytes with memory cell characteristics. A? 2012 European Molecular Biology Organization All Rights Reserved.
UR - http://www.nature.com/emboj/journal/v31/n3/pdf/emboj2011435a.pdf
U2 - 10.1038/emboj.2011.435
DO - 10.1038/emboj.2011.435
M3 - Article
VL - 31
SP - 692
EP - 706
JO - EMBO Journal
JF - EMBO Journal
SN - 0261-4189
IS - 3
ER -