The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

Raffi Gugasyan, Elisha Horat, Sarah Kinkel, Fiona Ross, George Grigoriadis, Daniel Gray, Meredith O'Keeffe, Stuart Berzins, Gabrielle Belz, Raelene Grumont, Ashish Banerjee, Andreas Strasser, Dale Godfrey, Philip Tsichlis, Steven Gerondakis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The role of specific members of the NF-I?B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-I?B1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF + thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-I?B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8 + thymocytes with memory cell characteristics. A? 2012 European Molecular Biology Organization All Rights Reserved.
Original languageEnglish
Pages (from-to)692 - 706
Number of pages15
JournalEMBO Journal
Volume31
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

Gugasyan, Raffi ; Horat, Elisha ; Kinkel, Sarah ; Ross, Fiona ; Grigoriadis, George ; Gray, Daniel ; O'Keeffe, Meredith ; Berzins, Stuart ; Belz, Gabrielle ; Grumont, Raelene ; Banerjee, Ashish ; Strasser, Andreas ; Godfrey, Dale ; Tsichlis, Philip ; Gerondakis, Steven. / The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. In: EMBO Journal. 2012 ; Vol. 31, No. 3. pp. 692 - 706.
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abstract = "The role of specific members of the NF-I?B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-I?B1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF + thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-I?B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8 + thymocytes with memory cell characteristics. A? 2012 European Molecular Biology Organization All Rights Reserved.",
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The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. / Gugasyan, Raffi; Horat, Elisha; Kinkel, Sarah; Ross, Fiona; Grigoriadis, George; Gray, Daniel; O'Keeffe, Meredith; Berzins, Stuart; Belz, Gabrielle; Grumont, Raelene; Banerjee, Ashish; Strasser, Andreas; Godfrey, Dale; Tsichlis, Philip; Gerondakis, Steven.

In: EMBO Journal, Vol. 31, No. 3, 2012, p. 692 - 706.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Gugasyan, Raffi

AU - Horat, Elisha

AU - Kinkel, Sarah

AU - Ross, Fiona

AU - Grigoriadis, George

AU - Gray, Daniel

AU - O'Keeffe, Meredith

AU - Berzins, Stuart

AU - Belz, Gabrielle

AU - Grumont, Raelene

AU - Banerjee, Ashish

AU - Strasser, Andreas

AU - Godfrey, Dale

AU - Tsichlis, Philip

AU - Gerondakis, Steven

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AB - The role of specific members of the NF-I?B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-I?B1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF + thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-I?B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8 + thymocytes with memory cell characteristics. A? 2012 European Molecular Biology Organization All Rights Reserved.

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