TY - JOUR
T1 - The neuropsychological spectrum of anti-LGI1 antibody mediated autoimmune encephalitis
AU - Griffith, Sarah P.
AU - Malpas, Charles B.
AU - Alpitsis, Rubina
AU - O'Brien, Terence J.
AU - Monif, Mastura
PY - 2020/8/15
Y1 - 2020/8/15
N2 - Anti-Leucine Glioma Inactivated 1 (LGI-1) autoimmune encephalitis (AE) is a rare neuroinflammatory brain condition. Individuals afflicted with this condition can present with cognitive and psychological manifestations that can impact the individual's quality of life, day to day functioning, independence, return to work and interpersonal relationships. Our knowledge of the cognitive profiles and disease associated psychopathology is severely lacking. This review provides a comprehensive summary of the currently available literature, conceptualising our current understanding of the neuropsychological manifestations of anti LGI-1 AE and summarises methodological limitations of the current research to inform and improve future investigations. Key Terms: Autoimmune Diseases; Neuroimmunology; Autoimmune Encephalitis, Limbic Encephalitis; Anti-LGI1 Encephalitis, LGI1; Neuropsychology, Cognitive Assessment.
AB - Anti-Leucine Glioma Inactivated 1 (LGI-1) autoimmune encephalitis (AE) is a rare neuroinflammatory brain condition. Individuals afflicted with this condition can present with cognitive and psychological manifestations that can impact the individual's quality of life, day to day functioning, independence, return to work and interpersonal relationships. Our knowledge of the cognitive profiles and disease associated psychopathology is severely lacking. This review provides a comprehensive summary of the currently available literature, conceptualising our current understanding of the neuropsychological manifestations of anti LGI-1 AE and summarises methodological limitations of the current research to inform and improve future investigations. Key Terms: Autoimmune Diseases; Neuroimmunology; Autoimmune Encephalitis, Limbic Encephalitis; Anti-LGI1 Encephalitis, LGI1; Neuropsychology, Cognitive Assessment.
UR - http://www.scopus.com/inward/record.url?scp=85085327108&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2020.577271
DO - 10.1016/j.jneuroim.2020.577271
M3 - Review Article
C2 - 32480239
AN - SCOPUS:85085327108
SN - 0165-5728
VL - 345
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577271
ER -