The neurobiology of cannabis use disorders: A call for evidence

Valentina Lorenzetti, Janna Cousijn, Nadia Solowij, Hugh Garavan, Chao Suo, Murat Yucel, Antonio Verdejo-Garcia

Research output: Contribution to journalArticleOtherpeer-review

10 Citations (Scopus)


Using cannabis is perceived by many as relatively harmless, but the adverse effects of problematic cannabis use are significant. Thirteen million individuals globally have Cannabis Use Disorders (CUDs; UNODC, 2015), with relapse rates comparable to those of other substance use disorders ( 52-70 ; Budney et al., 1999; Chauchard et al., 2013). Contrasting non-problematic recreational cannabis use, severe forms of CUD involve compulsive use despite significant harms to mental health; high stress levels (craving, withdrawal); cognitive deficits; academic and work absenteeism; and significant risky behaviors, such as driving and operating machinery while intoxicated. Worryingly, the concentration of Δ9-tetrahydrocannabinol, the compound driving the addiction liability of cannabis, has risen in cannabis products over the past decade (UNODC, 2015)
Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalFrontiers in Behavioral Neuroscience
Publication statusPublished - May 2016


  • neurobiology
  • cannabis use disorder
  • dependence
  • addiction
  • stress
  • physiological

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