The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry

H-Christian Von Bugingen, Feng Mei, Airele Greenfield, Sarah Jahn, Yun-An Shen, Hugh H Reid, David D McKemy, Jonah R Chan

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin. To date, the exact function of MOG has remained unknown, with MOG knockout mice displaying normal myelin ultrastructure and no apparent specific phenotype. In this paper, we identify nerve growth factor (NGF) as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival. Deletion of MOG results in aberrant sprouting of nociceptive neurons in the spinal cord. Binding of NGF to MOG may offer widespread implications into mechanisms that underlie pain pathways.
Original languageEnglish
Pages (from-to)891 - 898
Number of pages8
JournalJournal of Cell Biology
Volume210
Issue number6
DOIs
Publication statusPublished - 2015

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