The multifunctional Staufen proteins: Conserved roles from neurogenesis to synaptic plasticity

Jacki E. Heraud-Farlow; Michael A. Kiebler

doi:10.1016/j.tins.2014.05.009

The multifunctional Staufen proteins: Conserved roles from neurogenesis to synaptic plasticity

Jacki E. Heraud-Farlow, Michael A. Kiebler

Research output: Contribution to journal › Review Article › Research › peer-review

84 Citations (Scopus)

Abstract

Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of mature neurons. Recent molecular data suggest mechanisms for how Stau2 regulates mRNA localisation, mRNA stability, translation, and ribonucleoprotein (RNP) assembly. We offer a perspective on how this multifunctional RBP has been adopted to regulate mRNA localisation under several different cellular and developmental conditions.

Original language	English
Pages (from-to)	470-479
Number of pages	10
Journal	Trends in Neurosciences
Volume	37
Issue number	9
DOIs	https://doi.org/10.1016/j.tins.2014.05.009
Publication status	Published - Sept 2014
Externally published	Yes

Keywords

Learning and memory
MRNA stability
Neurogenesis
RNA localisation
RNP
Staufen
Synaptic plasticity

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10.1016/j.tins.2014.05.009

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title = "The multifunctional Staufen proteins: Conserved roles from neurogenesis to synaptic plasticity",

abstract = "Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of mature neurons. Recent molecular data suggest mechanisms for how Stau2 regulates mRNA localisation, mRNA stability, translation, and ribonucleoprotein (RNP) assembly. We offer a perspective on how this multifunctional RBP has been adopted to regulate mRNA localisation under several different cellular and developmental conditions.",

keywords = "Learning and memory, MRNA stability, Neurogenesis, RNA localisation, RNP, Staufen, Synaptic plasticity",

author = "Heraud-Farlow, \{Jacki E.\} and Kiebler, \{Michael A.\}",

note = "Funding Information: We thank Stefan H{\"u}ttelmaier, Dorothee Dormann, Dierk Niessing, Ashley Farlow, members of the laboratory of L.A.K., for comments on the manuscript. This work was supported by the Austrian Science Funds (I590-B09, SFB F43), the European Science Foundation (ESF) program RNAQuality (I 127-B12), and a Human Frontier Science Program (HFSP) network grant (RGP24/2008).",

year = "2014",

month = sep,

doi = "10.1016/j.tins.2014.05.009",

language = "English",

volume = "37",

pages = "470--479",

journal = "Trends in Neurosciences",

issn = "0166-2236",

publisher = "Cell Press",

number = "9",

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TY - JOUR

T1 - The multifunctional Staufen proteins

T2 - Conserved roles from neurogenesis to synaptic plasticity

AU - Heraud-Farlow, Jacki E.

AU - Kiebler, Michael A.

N1 - Funding Information: We thank Stefan Hüttelmaier, Dorothee Dormann, Dierk Niessing, Ashley Farlow, members of the laboratory of L.A.K., for comments on the manuscript. This work was supported by the Austrian Science Funds (I590-B09, SFB F43), the European Science Foundation (ESF) program RNAQuality (I 127-B12), and a Human Frontier Science Program (HFSP) network grant (RGP24/2008).

PY - 2014/9

Y1 - 2014/9

N2 - Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of mature neurons. Recent molecular data suggest mechanisms for how Stau2 regulates mRNA localisation, mRNA stability, translation, and ribonucleoprotein (RNP) assembly. We offer a perspective on how this multifunctional RBP has been adopted to regulate mRNA localisation under several different cellular and developmental conditions.

AB - Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of mature neurons. Recent molecular data suggest mechanisms for how Stau2 regulates mRNA localisation, mRNA stability, translation, and ribonucleoprotein (RNP) assembly. We offer a perspective on how this multifunctional RBP has been adopted to regulate mRNA localisation under several different cellular and developmental conditions.

KW - Learning and memory

KW - MRNA stability

KW - Neurogenesis

KW - RNA localisation

KW - RNP

KW - Staufen

KW - Synaptic plasticity

UR - http://www.scopus.com/inward/record.url?scp=84925767325&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2014.05.009

DO - 10.1016/j.tins.2014.05.009

M3 - Review Article

C2 - 25012293

AN - SCOPUS:84925767325

SN - 0166-2236

VL - 37

SP - 470

EP - 479

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 9

ER -

The multifunctional Staufen proteins: Conserved roles from neurogenesis to synaptic plasticity

Abstract

Keywords

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