The mucin antigens: What are we measuring?

M. R. Price, S. Briggs, M. J. Scanlon, S. J.B. Tendler, P. E.C. Sibley, C. W. Hand

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Serum of breast cancer patients contains high molecular weight, mucin-like glycoproteins which are held to be differentiation markers for certain types of normal epithelia, in particular mammary epithelium. These components have primarily been identified using monoclonal antibodies raised against human milk fat globule membranes, tumour extracts or purified mucins. Even so, many of the antibodies produced react with a discrete region of the mucin protein core involving the hydrophilic turn domain APDTRPAP. The present investigation using the anti-urinary mucin antibody, C595, illustrates both the clinical potential of the mucin antigens in breast cancer studies as well as the exquisite specificity of immune recognition of a complex polymorphic glycoprotein at the level of the individual amino acids.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalDisease Markers
Volume9
Issue number3-4
Publication statusPublished - 1 Jan 1991

Keywords

  • Breast cancer
  • Epithelial mucins
  • Monoclonal antibodies

Cite this

Price, M. R., Briggs, S., Scanlon, M. J., Tendler, S. J. B., Sibley, P. E. C., & Hand, C. W. (1991). The mucin antigens: What are we measuring? Disease Markers, 9(3-4), 205-212.
Price, M. R. ; Briggs, S. ; Scanlon, M. J. ; Tendler, S. J.B. ; Sibley, P. E.C. ; Hand, C. W. / The mucin antigens : What are we measuring?. In: Disease Markers. 1991 ; Vol. 9, No. 3-4. pp. 205-212.
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Price, MR, Briggs, S, Scanlon, MJ, Tendler, SJB, Sibley, PEC & Hand, CW 1991, 'The mucin antigens: What are we measuring?', Disease Markers, vol. 9, no. 3-4, pp. 205-212.

The mucin antigens : What are we measuring? / Price, M. R.; Briggs, S.; Scanlon, M. J.; Tendler, S. J.B.; Sibley, P. E.C.; Hand, C. W.

In: Disease Markers, Vol. 9, No. 3-4, 01.01.1991, p. 205-212.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The mucin antigens

T2 - What are we measuring?

AU - Price, M. R.

AU - Briggs, S.

AU - Scanlon, M. J.

AU - Tendler, S. J.B.

AU - Sibley, P. E.C.

AU - Hand, C. W.

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AB - Serum of breast cancer patients contains high molecular weight, mucin-like glycoproteins which are held to be differentiation markers for certain types of normal epithelia, in particular mammary epithelium. These components have primarily been identified using monoclonal antibodies raised against human milk fat globule membranes, tumour extracts or purified mucins. Even so, many of the antibodies produced react with a discrete region of the mucin protein core involving the hydrophilic turn domain APDTRPAP. The present investigation using the anti-urinary mucin antibody, C595, illustrates both the clinical potential of the mucin antigens in breast cancer studies as well as the exquisite specificity of immune recognition of a complex polymorphic glycoprotein at the level of the individual amino acids.

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KW - Epithelial mucins

KW - Monoclonal antibodies

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Price MR, Briggs S, Scanlon MJ, Tendler SJB, Sibley PEC, Hand CW. The mucin antigens: What are we measuring? Disease Markers. 1991 Jan 1;9(3-4):205-212.