Abstract
Serum of breast cancer patients contains high molecular weight, mucin-like glycoproteins which are held to be differentiation markers for certain types of normal epithelia, in particular mammary epithelium. These components have primarily been identified using monoclonal antibodies raised against human milk fat globule membranes, tumour extracts or purified mucins. Even so, many of the antibodies produced react with a discrete region of the mucin protein core involving the hydrophilic turn domain APDTRPAP. The present investigation using the anti-urinary mucin antibody, C595, illustrates both the clinical potential of the mucin antigens in breast cancer studies as well as the exquisite specificity of immune recognition of a complex polymorphic glycoprotein at the level of the individual amino acids.
| Original language | English |
|---|---|
| Pages (from-to) | 205-212 |
| Number of pages | 8 |
| Journal | Disease Markers |
| Volume | 9 |
| Issue number | 3-4 |
| Publication status | Published - 1 Jan 1991 |
Keywords
- Breast cancer
- Epithelial mucins
- Monoclonal antibodies
Cite this
}
The mucin antigens : What are we measuring? / Price, M. R.; Briggs, S.; Scanlon, M. J.; Tendler, S. J.B.; Sibley, P. E.C.; Hand, C. W.
In: Disease Markers, Vol. 9, No. 3-4, 01.01.1991, p. 205-212.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The mucin antigens
T2 - What are we measuring?
AU - Price, M. R.
AU - Briggs, S.
AU - Scanlon, M. J.
AU - Tendler, S. J.B.
AU - Sibley, P. E.C.
AU - Hand, C. W.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Serum of breast cancer patients contains high molecular weight, mucin-like glycoproteins which are held to be differentiation markers for certain types of normal epithelia, in particular mammary epithelium. These components have primarily been identified using monoclonal antibodies raised against human milk fat globule membranes, tumour extracts or purified mucins. Even so, many of the antibodies produced react with a discrete region of the mucin protein core involving the hydrophilic turn domain APDTRPAP. The present investigation using the anti-urinary mucin antibody, C595, illustrates both the clinical potential of the mucin antigens in breast cancer studies as well as the exquisite specificity of immune recognition of a complex polymorphic glycoprotein at the level of the individual amino acids.
AB - Serum of breast cancer patients contains high molecular weight, mucin-like glycoproteins which are held to be differentiation markers for certain types of normal epithelia, in particular mammary epithelium. These components have primarily been identified using monoclonal antibodies raised against human milk fat globule membranes, tumour extracts or purified mucins. Even so, many of the antibodies produced react with a discrete region of the mucin protein core involving the hydrophilic turn domain APDTRPAP. The present investigation using the anti-urinary mucin antibody, C595, illustrates both the clinical potential of the mucin antigens in breast cancer studies as well as the exquisite specificity of immune recognition of a complex polymorphic glycoprotein at the level of the individual amino acids.
KW - Breast cancer
KW - Epithelial mucins
KW - Monoclonal antibodies
UR - http://www.scopus.com/inward/record.url?scp=0025788343&partnerID=8YFLogxK
M3 - Article
C2 - 1725974
AN - SCOPUS:0025788343
VL - 9
SP - 205
EP - 212
JO - Disease Markers
JF - Disease Markers
SN - 0278-0240
IS - 3-4
ER -