The MSBase pregnancy, neonatal outcomes, and women’s health registry

Vilija G. Jokubaitis, Olga Skibina, Raed Alroughani, Ayse Altintas, Helmut Butzkueven, Sara Eichau, Yara Fragoso, Kerstin Hellwig, Stella E. Hughes, Louise Rath, Anneke van der Walt, Orla Gray

Research output: Contribution to journalArticleOtherpeer-review

Abstract

Background: Family planning and pregnancy decisions are key considerations in the management of women with multiple sclerosis (MS), who are typically diagnosed between the ages of 20–40 years. Despite a strong evidence base that pregnancy is not harmful for women with MS, many knowledge gaps remain. These include: best management strategies through pregnancy in the era of highly effective disease-modifying therapies (DMT); foetal risks associated with DMT exposure in utero or in relation to breastfeeding; knowledge base around the use of assisted reproductive technologies; the long-term impact of pregnancy on disease outcomes, as well as the impact of long-term DMT use on women’s health and cancer risk. Methods: Here, we describe the new MSBase pregnancy, neonatal outcomes and women’s health registry. We provide the rationale for, and detailed description of, the variables collected within the registry, together with data acquisition details. Conclusion: The present paper will act as a reference document for future studies.

Original languageEnglish
Number of pages8
JournalTherapeutic Advances in Neurological Disorders
Volume14
DOIs
Publication statusPublished - 2021

Keywords

  • MSBase
  • Multiple Sclerosis
  • Neonatal Outcomes
  • Pregnancy
  • Registry
  • Women’s Health

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