The mRNA decay pathway regulates expressionof the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae

Tricia Liang Lo, Yue Qu, Nathalie Uwamahoro, Tara L Quenault, Traude H Beilharz, Ana Traven

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription.
Original languageEnglish
Pages (from-to)1387 - 1391
Number of pages5
Issue number4
Publication statusPublished - 2012

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