The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity

P. Mark Hogarth, Margaret L. Hibbs, Lisa Bonadonna, Bernadette M. Scott, Ewa Witort, Geoffrey Pietersz, Ian F. C. McKenzie

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34 Citations (Scopus)

Abstract

A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional FcγR investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgGγ1/2b and rabbit IgG complexes.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalImmunogenetics
Volume26
Issue number3
DOIs
Publication statusPublished - 1 Sep 1987
Externally publishedYes

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