The mouse ascending: perspectives for human-disease models

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Abstract

The laboratory mouse is widely considered the model organism of choice for studying the diseases of humans, with whom they share 99 of their genes. A distinguished history of mouse genetic experimentation has been further advanced by the development of powerful new tools to manipulate the mouse genome. The recent launch of several international initiatives to analyse the function of all mouse genes through mutagenesis, molecular analysis and phenotyping underscores the utility of the mouse for translating the information stored in the human genome into increasingly accurate models of human disease.
Original languageEnglish
Pages (from-to)993 - 999
Number of pages7
JournalNature Cell Biology
Volume9
Issue number9
Publication statusPublished - 2007
Externally publishedYes

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