The molecular mechanisms of severe typhoid fever

Paul Everest, John Wain, Mark Roberts, Graham Rook, Gordon Dougan

Research output: Contribution to journalReview ArticleResearchpeer-review

98 Citations (Scopus)


Salmonella typhicontinues to cause severe disease in many parts of the world, its most feared complication being perforation of ulcerated Peyer's patches within the small intestine, leading to peritonitis with associated mortality. The pathogenesis of this process is not well understood. In this article, we present a theoretical mechanism as to how bacterial factors and host immunological mediators within infected tissue might contribute to the observed intestinal pathology, and propose that necrosis of the Peyer's patches observed in typhoid is caused by a mechanism similar to the Shwartzman and Koch reactions.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalTrends in Microbiology
Issue number7
Publication statusPublished - 1 Jul 2001
Externally publishedYes

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