The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo

C Burns, Emmanuelle Fantino, Andrew Powell, Steven Shnyder, Patricia Cooper, Stuart Nelson, Christopher Christophi, Cathy Malcontenti-Wilson, Valentina Dubljevic, Michael Harte, Max Joffe, Ian Phillips, David Segal, Andrew Wilks, Gregg Smith

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

The orally active microtubule disrupting agent CYT997, previously reported by us, is potently cytotoxic to a variety of cancer cell lines in vitro and shows anti-tumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterise the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the compound on endothelial cells in vitro and on tumor blood flow in vivo using a variety of techniques.
Original languageEnglish
Pages (from-to)799 - 806
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume339
Issue number3
DOIs
Publication statusPublished - 2011

Cite this

Burns, C ; Fantino, Emmanuelle ; Powell, Andrew ; Shnyder, Steven ; Cooper, Patricia ; Nelson, Stuart ; Christophi, Christopher ; Malcontenti-Wilson, Cathy ; Dubljevic, Valentina ; Harte, Michael ; Joffe, Max ; Phillips, Ian ; Segal, David ; Wilks, Andrew ; Smith, Gregg. / The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo. In: Journal of Pharmacology and Experimental Therapeutics. 2011 ; Vol. 339, No. 3. pp. 799 - 806.
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title = "The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo",
abstract = "The orally active microtubule disrupting agent CYT997, previously reported by us, is potently cytotoxic to a variety of cancer cell lines in vitro and shows anti-tumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterise the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the compound on endothelial cells in vitro and on tumor blood flow in vivo using a variety of techniques.",
author = "C Burns and Emmanuelle Fantino and Andrew Powell and Steven Shnyder and Patricia Cooper and Stuart Nelson and Christopher Christophi and Cathy Malcontenti-Wilson and Valentina Dubljevic and Michael Harte and Max Joffe and Ian Phillips and David Segal and Andrew Wilks and Gregg Smith",
year = "2011",
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language = "English",
volume = "339",
pages = "799 -- 806",
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Burns, C, Fantino, E, Powell, A, Shnyder, S, Cooper, P, Nelson, S, Christophi, C, Malcontenti-Wilson, C, Dubljevic, V, Harte, M, Joffe, M, Phillips, I, Segal, D, Wilks, A & Smith, G 2011, 'The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo', Journal of Pharmacology and Experimental Therapeutics, vol. 339, no. 3, pp. 799 - 806. https://doi.org/10.1124/jpet.111.186965

The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo. / Burns, C; Fantino, Emmanuelle; Powell, Andrew; Shnyder, Steven; Cooper, Patricia; Nelson, Stuart; Christophi, Christopher; Malcontenti-Wilson, Cathy; Dubljevic, Valentina; Harte, Michael; Joffe, Max; Phillips, Ian; Segal, David; Wilks, Andrew; Smith, Gregg.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 339, No. 3, 2011, p. 799 - 806.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo

AU - Burns, C

AU - Fantino, Emmanuelle

AU - Powell, Andrew

AU - Shnyder, Steven

AU - Cooper, Patricia

AU - Nelson, Stuart

AU - Christophi, Christopher

AU - Malcontenti-Wilson, Cathy

AU - Dubljevic, Valentina

AU - Harte, Michael

AU - Joffe, Max

AU - Phillips, Ian

AU - Segal, David

AU - Wilks, Andrew

AU - Smith, Gregg

PY - 2011

Y1 - 2011

N2 - The orally active microtubule disrupting agent CYT997, previously reported by us, is potently cytotoxic to a variety of cancer cell lines in vitro and shows anti-tumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterise the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the compound on endothelial cells in vitro and on tumor blood flow in vivo using a variety of techniques.

AB - The orally active microtubule disrupting agent CYT997, previously reported by us, is potently cytotoxic to a variety of cancer cell lines in vitro and shows anti-tumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterise the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the compound on endothelial cells in vitro and on tumor blood flow in vivo using a variety of techniques.

UR - http://jpet.aspetjournals.org/content/early/2011/09/14/jpet.111.186965.short?rss=1

U2 - 10.1124/jpet.111.186965

DO - 10.1124/jpet.111.186965

M3 - Article

VL - 339

SP - 799

EP - 806

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 3

ER -