TY - JOUR
T1 - The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo
AU - Burns, C
AU - Fantino, Emmanuelle
AU - Powell, Andrew
AU - Shnyder, Steven
AU - Cooper, Patricia
AU - Nelson, Stuart
AU - Christophi, Christopher
AU - Malcontenti-Wilson, Cathy
AU - Dubljevic, Valentina
AU - Harte, Michael
AU - Joffe, Max
AU - Phillips, Ian
AU - Segal, David
AU - Wilks, Andrew
AU - Smith, Gregg
PY - 2011
Y1 - 2011
N2 - The orally active microtubule disrupting agent CYT997, previously reported by us, is potently cytotoxic to a variety of cancer cell lines in vitro and shows anti-tumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterise the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the compound on endothelial cells in vitro and on tumor blood flow in vivo using a variety of techniques.
AB - The orally active microtubule disrupting agent CYT997, previously reported by us, is potently cytotoxic to a variety of cancer cell lines in vitro and shows anti-tumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterise the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the compound on endothelial cells in vitro and on tumor blood flow in vivo using a variety of techniques.
UR - http://jpet.aspetjournals.org/content/early/2011/09/14/jpet.111.186965.short?rss=1
U2 - 10.1124/jpet.111.186965
DO - 10.1124/jpet.111.186965
M3 - Article
SN - 0022-3565
VL - 339
SP - 799
EP - 806
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
IS - 3
ER -
