The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo

C Burns, Emmanuelle Fantino, Andrew Powell, Steven Shnyder, Patricia Cooper, Stuart Nelson, Christopher Christophi, Cathy Malcontenti-Wilson, Valentina Dubljevic, Michael Harte, Max Joffe, Ian Phillips, David Segal, Andrew Wilks, Gregg Smith

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12 Citations (Scopus)

Abstract

The orally active microtubule disrupting agent CYT997, previously reported by us, is potently cytotoxic to a variety of cancer cell lines in vitro and shows anti-tumor activity in vivo. In addition to its cytotoxic activity, CYT997 possesses antivascular effects on tumor vasculature. To further characterise the vascular disrupting activity of CYT997 in terms of dose and temporal effects, we studied the activity of the compound on endothelial cells in vitro and on tumor blood flow in vivo using a variety of techniques.
Original languageEnglish
Pages (from-to)799 - 806
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume339
Issue number3
DOIs
Publication statusPublished - 2011

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