The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility

Ravichandra Vemuri, Kristyn E. Sylvia, Sabra L. Klein, Samuel C. Forster, Magdalena Plebanski, Raj Eri, Katie L. Flanagan

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Sex differences in immunity are well described in the literature and thought to be mainly driven by sex hormones and sex-linked immune response genes. The gastrointestinal tract (GIT) is one of the largest immune organs in the body and contains multiple immune cells in the GIT-associated lymphoid tissue, Peyer’s patches and elsewhere, which together have profound effects on local and systemic inflammation. The GIT is colonised with microbial communities composed of bacteria, fungi and viruses, collectively known as the GIT microbiota. The GIT microbiota drives multiple interactions locally with immune cells that regulate the homeostatic environment and systemically in diverse tissues. It is becoming evident that the microbiota differs between the sexes, both in animal models and in humans, and these sex differences often lead to sex-dependent changes in local GIT inflammation, systemic immunity and susceptibility to a range of inflammatory diseases. The sexually dimorphic microbiome has been termed the ‘microgenderome’. Herein, we review the evidence for the microgenderome and contemplate the role it plays in driving sex differences in immunity and disease susceptibility. We further consider the impact that biological sex might play in the response to treatments aimed at manipulating the GIT microbiota, such as prebiotics, live biotherapeutics, (probiotics, synbiotics and bacteriotherapies) and faecal microbial transplant. These alternative therapies hold potential in the treatment of both psychological (e.g., anxiety, depression) and physiological (e.g., irritable bowel disease) disorders differentially affecting males and females.

Original languageEnglish
Pages (from-to)265-275
Number of pages11
JournalSeminars in Immunopathology
Volume41
Issue number2
DOIs
Publication statusPublished - 15 Mar 2019

Keywords

  • Adaptive immunity
  • Bacteriotherapy
  • Faecal microbiota transplant
  • Innate immunity
  • Probiotics
  • Sex differences
  • Sex hormones

Cite this

@article{e04b8327a02e455d949f8568e54987c3,
title = "The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility",
abstract = "Sex differences in immunity are well described in the literature and thought to be mainly driven by sex hormones and sex-linked immune response genes. The gastrointestinal tract (GIT) is one of the largest immune organs in the body and contains multiple immune cells in the GIT-associated lymphoid tissue, Peyer’s patches and elsewhere, which together have profound effects on local and systemic inflammation. The GIT is colonised with microbial communities composed of bacteria, fungi and viruses, collectively known as the GIT microbiota. The GIT microbiota drives multiple interactions locally with immune cells that regulate the homeostatic environment and systemically in diverse tissues. It is becoming evident that the microbiota differs between the sexes, both in animal models and in humans, and these sex differences often lead to sex-dependent changes in local GIT inflammation, systemic immunity and susceptibility to a range of inflammatory diseases. The sexually dimorphic microbiome has been termed the ‘microgenderome’. Herein, we review the evidence for the microgenderome and contemplate the role it plays in driving sex differences in immunity and disease susceptibility. We further consider the impact that biological sex might play in the response to treatments aimed at manipulating the GIT microbiota, such as prebiotics, live biotherapeutics, (probiotics, synbiotics and bacteriotherapies) and faecal microbial transplant. These alternative therapies hold potential in the treatment of both psychological (e.g., anxiety, depression) and physiological (e.g., irritable bowel disease) disorders differentially affecting males and females.",
keywords = "Adaptive immunity, Bacteriotherapy, Faecal microbiota transplant, Innate immunity, Probiotics, Sex differences, Sex hormones",
author = "Ravichandra Vemuri and Sylvia, {Kristyn E.} and Klein, {Sabra L.} and Forster, {Samuel C.} and Magdalena Plebanski and Raj Eri and Flanagan, {Katie L.}",
year = "2019",
month = "3",
day = "15",
doi = "10.1007/s00281-018-0716-7",
language = "English",
volume = "41",
pages = "265--275",
journal = "Seminars in Immunopathology",
issn = "1863-2297",
publisher = "Springer",
number = "2",

}

The microgenderome revealed : sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility. / Vemuri, Ravichandra; Sylvia, Kristyn E.; Klein, Sabra L.; Forster, Samuel C.; Plebanski, Magdalena; Eri, Raj; Flanagan, Katie L.

In: Seminars in Immunopathology, Vol. 41, No. 2, 15.03.2019, p. 265-275.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - The microgenderome revealed

T2 - sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility

AU - Vemuri, Ravichandra

AU - Sylvia, Kristyn E.

AU - Klein, Sabra L.

AU - Forster, Samuel C.

AU - Plebanski, Magdalena

AU - Eri, Raj

AU - Flanagan, Katie L.

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Sex differences in immunity are well described in the literature and thought to be mainly driven by sex hormones and sex-linked immune response genes. The gastrointestinal tract (GIT) is one of the largest immune organs in the body and contains multiple immune cells in the GIT-associated lymphoid tissue, Peyer’s patches and elsewhere, which together have profound effects on local and systemic inflammation. The GIT is colonised with microbial communities composed of bacteria, fungi and viruses, collectively known as the GIT microbiota. The GIT microbiota drives multiple interactions locally with immune cells that regulate the homeostatic environment and systemically in diverse tissues. It is becoming evident that the microbiota differs between the sexes, both in animal models and in humans, and these sex differences often lead to sex-dependent changes in local GIT inflammation, systemic immunity and susceptibility to a range of inflammatory diseases. The sexually dimorphic microbiome has been termed the ‘microgenderome’. Herein, we review the evidence for the microgenderome and contemplate the role it plays in driving sex differences in immunity and disease susceptibility. We further consider the impact that biological sex might play in the response to treatments aimed at manipulating the GIT microbiota, such as prebiotics, live biotherapeutics, (probiotics, synbiotics and bacteriotherapies) and faecal microbial transplant. These alternative therapies hold potential in the treatment of both psychological (e.g., anxiety, depression) and physiological (e.g., irritable bowel disease) disorders differentially affecting males and females.

AB - Sex differences in immunity are well described in the literature and thought to be mainly driven by sex hormones and sex-linked immune response genes. The gastrointestinal tract (GIT) is one of the largest immune organs in the body and contains multiple immune cells in the GIT-associated lymphoid tissue, Peyer’s patches and elsewhere, which together have profound effects on local and systemic inflammation. The GIT is colonised with microbial communities composed of bacteria, fungi and viruses, collectively known as the GIT microbiota. The GIT microbiota drives multiple interactions locally with immune cells that regulate the homeostatic environment and systemically in diverse tissues. It is becoming evident that the microbiota differs between the sexes, both in animal models and in humans, and these sex differences often lead to sex-dependent changes in local GIT inflammation, systemic immunity and susceptibility to a range of inflammatory diseases. The sexually dimorphic microbiome has been termed the ‘microgenderome’. Herein, we review the evidence for the microgenderome and contemplate the role it plays in driving sex differences in immunity and disease susceptibility. We further consider the impact that biological sex might play in the response to treatments aimed at manipulating the GIT microbiota, such as prebiotics, live biotherapeutics, (probiotics, synbiotics and bacteriotherapies) and faecal microbial transplant. These alternative therapies hold potential in the treatment of both psychological (e.g., anxiety, depression) and physiological (e.g., irritable bowel disease) disorders differentially affecting males and females.

KW - Adaptive immunity

KW - Bacteriotherapy

KW - Faecal microbiota transplant

KW - Innate immunity

KW - Probiotics

KW - Sex differences

KW - Sex hormones

UR - http://www.scopus.com/inward/record.url?scp=85054729395&partnerID=8YFLogxK

U2 - 10.1007/s00281-018-0716-7

DO - 10.1007/s00281-018-0716-7

M3 - Review Article

VL - 41

SP - 265

EP - 275

JO - Seminars in Immunopathology

JF - Seminars in Immunopathology

SN - 1863-2297

IS - 2

ER -