The microbiota and susceptibility to asthma

Olawale Salami, Benjamin J. Marsland

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Asthma is a common chronic respiratory disease that affects millions of people of all ages in every part of the world. A growing body of epidemiological evidence suggests that early-life exposure to environment-derived microbes and farm milk consumption confer protection against allergic disorders. Culture-independent analyses performed on the human microbiome have provided an overview of microbial communities in various tissue habitats. This chapter provides a synopsis of current knowledge of the airway microbiota and how dysbiosis may underlie the susceptibility to the severity and persistence of asthma and other chronic lung diseases. Sampling of the bronchoal-veolar space by bronchoalveolar lavage (BAL) remains an important tool for clinical diagnoses as well as experimental models of lung diseases. The development of the airway microbiota in the neonate may be influenced by the: intra-uterine microbial exposure, perinatal events, breast-milk as a source of airway microbiota, airborne microbiota, and microbiota of the upper airways.

Original languageEnglish
Title of host publicationThe Human Microbiota and Chronic Disease
Subtitle of host publicationDysbiosis as a Cause of Human Pathology
EditorsLuigi Nibali, Brian Henderson
PublisherWiley-Blackwell
Chapter24
Pages361-370
Number of pages10
ISBN (Electronic)9781118982907
ISBN (Print)9781118982877
DOIs
Publication statusPublished - 22 Sep 2016
Externally publishedYes

Keywords

  • Allergic disorders
  • Asthma
  • Bronchoalveolar lavage
  • Chronic respiratory disease
  • Human microbiome
  • Human microbiota
  • Upper airway microbiota

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