The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

Yvonne J. Huang, Benjamin J. Marsland, Supinda Bunyavanich, Liam O'Mahony, Donald Y.M. Leung, Antonella Muraro, Thomas A. Fleisher

Research output: Contribution to journalArticleOtherpeer-review

110 Citations (Scopus)

Abstract

PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology to provide shared evidence-based recommendations on cutting-edge topics in the field of allergy and immunology. PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, and food allergy. This is complemented by outlining important knowledge gaps regarding its role in allergic disease and delineating strategies necessary to fill these gaps. In addition, a review of progress in approaches used to manipulate the microbiome will be addressed, identifying what has and has not worked to serve as a baseline for future directions to intervene in allergic disease development, progression, or both.

Original languageEnglish
Pages (from-to)1099-1110
Number of pages12
JournalJournal of Allergy and Clinical Immunology
Volume139
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017
Externally publishedYes

Keywords

  • asthma
  • atopic dermatitis
  • dysbiosis
  • food allergy
  • Microbiome
  • microbiota
  • prebiotic
  • probiotic
  • systems biology

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