The metabolic and endocrine response to trauma

Amy Krepska, Jennifer Hastings, Owen Roodenburg

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)


Metabolic and endocrine pathways are central to the body's compensatory response to trauma. They drive mobilization of energy substrates, volume conservation and haemostasis via activation of the hypothalamic pituitary adrenal axis, the sympathetic nervous system and an inflammatory response. As clinicians, we can intervene in these pathways, however optimal management of anaesthesia, fluids, transfusion, nutrition and the use of steroids remains controversial and to be determined.

Original languageEnglish
Pages (from-to)414-417
Number of pages4
JournalAnaesthesia and Intensive Care Medicine
Issue number8
Publication statusPublished - 1 Aug 2017


  • Catecholamines
  • coagulation
  • cortisol
  • enhanced recovery pathway
  • fibrinogen
  • gluconeogenesis
  • glutamine
  • hypothalamic pituitary axis
  • inflammatory mediators
  • regional anaesthesia
  • renin angiotensin aldosterone system
  • transfusion

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