The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

Mirko Koziolek, Stefano Alcaro, Patrick Augustijns, Abdul W. Basit, Michael Grimm, Bart Hens, Caroline L. Hoad, Philipp Jedamzik, Christine M. Madla, Marc Maliepaard, Luca Marciani, Annalisa Maruca, Neil Parrott, Petr Pávek, Christopher J.H. Porter, Christos Reppas, Diana van Riet-Nales, Jari Rubbens, Marina Statelova, Natalie L. Trevaskis & 4 others Kateřina Valentová, Maria Vertzoni, Dubravka Vitali Čepo, Maura Corsetti

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of the main challenges in oral drug administration. Whereas pharmacokinetic (PK) food-drug interactions can have a variety of causes, pharmacodynamic (PD) food-drug interactions occur due to specific pharmacological interactions between a drug and particular drinks or food. In recent years, extensive efforts were made to elucidate the mechanisms that drive pharmacokinetic food-drug interactions. Their occurrence depends mainly on the properties of the drug substance, the formulation and a multitude of physiological factors. Every intake of food or drink changes the physiological conditions in the human gastrointestinal tract. Therefore, a precise understanding of how different foods and drinks affect the processes of drug absorption, distribution, metabolism and/or elimination as well as formulation performance is important in order to be able to predict and avoid such interactions. Furthermore, it must be considered that beverages such as milk, grapefruit juice and alcohol can also lead to specific food-drug interactions. In this regard, the growing use of food supplements and functional food requires urgent attention in oral pharmacotherapy. Recently, a new consortium in Understanding Gastrointestinal Absorption-related Processes (UNGAP) was established through COST, a funding organisation of the European Union supporting translational research across Europe. In this review of the UNGAP Working group “Food-Drug Interface”, the different mechanisms that can lead to pharmacokinetic food-drug interactions are discussed and summarised from different expert perspectives.

Original languageEnglish
Pages (from-to)31-59
Number of pages29
JournalEuropean Journal of Pharmaceutical Sciences
Volume134
DOIs
Publication statusPublished - 15 Jun 2019

Keywords

  • Absorption
  • Drug release
  • Food effect
  • Food-drug interaction
  • Metabolism
  • Oral bioavailability
  • Oral drug delivery

Cite this

Koziolek, Mirko ; Alcaro, Stefano ; Augustijns, Patrick ; Basit, Abdul W. ; Grimm, Michael ; Hens, Bart ; Hoad, Caroline L. ; Jedamzik, Philipp ; Madla, Christine M. ; Maliepaard, Marc ; Marciani, Luca ; Maruca, Annalisa ; Parrott, Neil ; Pávek, Petr ; Porter, Christopher J.H. ; Reppas, Christos ; van Riet-Nales, Diana ; Rubbens, Jari ; Statelova, Marina ; Trevaskis, Natalie L. ; Valentová, Kateřina ; Vertzoni, Maria ; Čepo, Dubravka Vitali ; Corsetti, Maura. / The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group. In: European Journal of Pharmaceutical Sciences. 2019 ; Vol. 134. pp. 31-59.
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abstract = "The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of the main challenges in oral drug administration. Whereas pharmacokinetic (PK) food-drug interactions can have a variety of causes, pharmacodynamic (PD) food-drug interactions occur due to specific pharmacological interactions between a drug and particular drinks or food. In recent years, extensive efforts were made to elucidate the mechanisms that drive pharmacokinetic food-drug interactions. Their occurrence depends mainly on the properties of the drug substance, the formulation and a multitude of physiological factors. Every intake of food or drink changes the physiological conditions in the human gastrointestinal tract. Therefore, a precise understanding of how different foods and drinks affect the processes of drug absorption, distribution, metabolism and/or elimination as well as formulation performance is important in order to be able to predict and avoid such interactions. Furthermore, it must be considered that beverages such as milk, grapefruit juice and alcohol can also lead to specific food-drug interactions. In this regard, the growing use of food supplements and functional food requires urgent attention in oral pharmacotherapy. Recently, a new consortium in Understanding Gastrointestinal Absorption-related Processes (UNGAP) was established through COST, a funding organisation of the European Union supporting translational research across Europe. In this review of the UNGAP Working group “Food-Drug Interface”, the different mechanisms that can lead to pharmacokinetic food-drug interactions are discussed and summarised from different expert perspectives.",
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author = "Mirko Koziolek and Stefano Alcaro and Patrick Augustijns and Basit, {Abdul W.} and Michael Grimm and Bart Hens and Hoad, {Caroline L.} and Philipp Jedamzik and Madla, {Christine M.} and Marc Maliepaard and Luca Marciani and Annalisa Maruca and Neil Parrott and Petr P{\'a}vek and Porter, {Christopher J.H.} and Christos Reppas and {van Riet-Nales}, Diana and Jari Rubbens and Marina Statelova and Trevaskis, {Natalie L.} and Kateřina Valentov{\'a} and Maria Vertzoni and Čepo, {Dubravka Vitali} and Maura Corsetti",
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Koziolek, M, Alcaro, S, Augustijns, P, Basit, AW, Grimm, M, Hens, B, Hoad, CL, Jedamzik, P, Madla, CM, Maliepaard, M, Marciani, L, Maruca, A, Parrott, N, Pávek, P, Porter, CJH, Reppas, C, van Riet-Nales, D, Rubbens, J, Statelova, M, Trevaskis, NL, Valentová, K, Vertzoni, M, Čepo, DV & Corsetti, M 2019, 'The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group' European Journal of Pharmaceutical Sciences, vol. 134, pp. 31-59. https://doi.org/10.1016/j.ejps.2019.04.003

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group. / Koziolek, Mirko; Alcaro, Stefano; Augustijns, Patrick; Basit, Abdul W.; Grimm, Michael; Hens, Bart; Hoad, Caroline L.; Jedamzik, Philipp; Madla, Christine M.; Maliepaard, Marc; Marciani, Luca; Maruca, Annalisa; Parrott, Neil; Pávek, Petr; Porter, Christopher J.H.; Reppas, Christos; van Riet-Nales, Diana; Rubbens, Jari; Statelova, Marina; Trevaskis, Natalie L.; Valentová, Kateřina; Vertzoni, Maria; Čepo, Dubravka Vitali; Corsetti, Maura.

In: European Journal of Pharmaceutical Sciences, Vol. 134, 15.06.2019, p. 31-59.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Koziolek, Mirko

AU - Alcaro, Stefano

AU - Augustijns, Patrick

AU - Basit, Abdul W.

AU - Grimm, Michael

AU - Hens, Bart

AU - Hoad, Caroline L.

AU - Jedamzik, Philipp

AU - Madla, Christine M.

AU - Maliepaard, Marc

AU - Marciani, Luca

AU - Maruca, Annalisa

AU - Parrott, Neil

AU - Pávek, Petr

AU - Porter, Christopher J.H.

AU - Reppas, Christos

AU - van Riet-Nales, Diana

AU - Rubbens, Jari

AU - Statelova, Marina

AU - Trevaskis, Natalie L.

AU - Valentová, Kateřina

AU - Vertzoni, Maria

AU - Čepo, Dubravka Vitali

AU - Corsetti, Maura

PY - 2019/6/15

Y1 - 2019/6/15

N2 - The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of the main challenges in oral drug administration. Whereas pharmacokinetic (PK) food-drug interactions can have a variety of causes, pharmacodynamic (PD) food-drug interactions occur due to specific pharmacological interactions between a drug and particular drinks or food. In recent years, extensive efforts were made to elucidate the mechanisms that drive pharmacokinetic food-drug interactions. Their occurrence depends mainly on the properties of the drug substance, the formulation and a multitude of physiological factors. Every intake of food or drink changes the physiological conditions in the human gastrointestinal tract. Therefore, a precise understanding of how different foods and drinks affect the processes of drug absorption, distribution, metabolism and/or elimination as well as formulation performance is important in order to be able to predict and avoid such interactions. Furthermore, it must be considered that beverages such as milk, grapefruit juice and alcohol can also lead to specific food-drug interactions. In this regard, the growing use of food supplements and functional food requires urgent attention in oral pharmacotherapy. Recently, a new consortium in Understanding Gastrointestinal Absorption-related Processes (UNGAP) was established through COST, a funding organisation of the European Union supporting translational research across Europe. In this review of the UNGAP Working group “Food-Drug Interface”, the different mechanisms that can lead to pharmacokinetic food-drug interactions are discussed and summarised from different expert perspectives.

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KW - Absorption

KW - Drug release

KW - Food effect

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