Abstract
Immune cell recruitment and migration is central to the normal functioning of the immune system in health and disease. Numerous adhesion molecules on immune cells and the parenchymal cells they interact with are well recognized for their roles in facilitating the movements of immune cells throughout the body. A growing body of evidence now indicates that tetraspanins, proteins known for their capacity to organize partner molecules within the cell membrane, also have significant impacts on the ability of immune cells to migrate around the body. In this review, we examine the tetraspanins expressed by immune cells and endothelial cells that influence leukocyte recruitment and motility and describe their impacts on the function of adhesion molecules and other partner molecules that modulate the movements of leukocytes. In particular, we examine the functional roles of CD9, CD37, CD63, CD81, CD82, and CD151. This reveals the diversity of the functions of the tetraspanin family in this setting, both in the nature of adhesive and migratory interactions that they regulate, and the positive or inhibitory effects mediated by the individual tetraspanin proteins.
| Original language | English |
|---|---|
| Article number | 1644 |
| Number of pages | 11 |
| Journal | Frontiers in Immunology |
| Volume | 9 |
| Issue number | JUL |
| DOIs | |
| Publication status | Published - 18 Jul 2018 |
Keywords
- Adhesion molecules
- Inflammation
- Integrins
- Leukocyte migration
- Tetraspanin
Cite this
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The many and varied roles of tetraspanins in immune cell recruitment and migration. / Yeung, Louisa; Hickey, Michael J.; Wright, Mark D.
In: Frontiers in Immunology, Vol. 9, No. JUL, 1644, 18.07.2018.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The many and varied roles of tetraspanins in immune cell recruitment and migration
AU - Yeung, Louisa
AU - Hickey, Michael J.
AU - Wright, Mark D.
PY - 2018/7/18
Y1 - 2018/7/18
N2 - Immune cell recruitment and migration is central to the normal functioning of the immune system in health and disease. Numerous adhesion molecules on immune cells and the parenchymal cells they interact with are well recognized for their roles in facilitating the movements of immune cells throughout the body. A growing body of evidence now indicates that tetraspanins, proteins known for their capacity to organize partner molecules within the cell membrane, also have significant impacts on the ability of immune cells to migrate around the body. In this review, we examine the tetraspanins expressed by immune cells and endothelial cells that influence leukocyte recruitment and motility and describe their impacts on the function of adhesion molecules and other partner molecules that modulate the movements of leukocytes. In particular, we examine the functional roles of CD9, CD37, CD63, CD81, CD82, and CD151. This reveals the diversity of the functions of the tetraspanin family in this setting, both in the nature of adhesive and migratory interactions that they regulate, and the positive or inhibitory effects mediated by the individual tetraspanin proteins.
AB - Immune cell recruitment and migration is central to the normal functioning of the immune system in health and disease. Numerous adhesion molecules on immune cells and the parenchymal cells they interact with are well recognized for their roles in facilitating the movements of immune cells throughout the body. A growing body of evidence now indicates that tetraspanins, proteins known for their capacity to organize partner molecules within the cell membrane, also have significant impacts on the ability of immune cells to migrate around the body. In this review, we examine the tetraspanins expressed by immune cells and endothelial cells that influence leukocyte recruitment and motility and describe their impacts on the function of adhesion molecules and other partner molecules that modulate the movements of leukocytes. In particular, we examine the functional roles of CD9, CD37, CD63, CD81, CD82, and CD151. This reveals the diversity of the functions of the tetraspanin family in this setting, both in the nature of adhesive and migratory interactions that they regulate, and the positive or inhibitory effects mediated by the individual tetraspanin proteins.
KW - Adhesion molecules
KW - Inflammation
KW - Integrins
KW - Leukocyte migration
KW - Tetraspanin
UR - http://www.scopus.com/inward/record.url?scp=85050083077&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2018.01644
DO - 10.3389/fimmu.2018.01644
M3 - Review Article
VL - 9
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - JUL
M1 - 1644
ER -