The mammalian gene function resource: The International Knockout Mouse Consortium

Allan Bradley; Konstantinos Anastassiadis; Abdelkader Ayadi; James F. Battey; Cindy Bell; Marie Christine Birling; Joanna R Bottomley; Steve D. Brown; Antje Bürger; Carol J. Bult; Wendy Bushell; Francis S. Collins; Christian Desaintes; Brendan Doe; Economides Aris; Janan T. Eppig; Richard H. Finnell; Colin Fletcher; Martin Fray; David Frendewey; Roland H. Friedel; Frank G. Grosveld; Jens Hansen; Yann Hérault; Geoffrey Hicks; Andreas Hörlein; Richard Houghton; Martin Hrabé De Angelis; Danny Huylebroeck; Vivek Iyer; Pieter J. De Jong; James A. Kadin; Cornelia Kaloff; Karen Kennedy; Manousos Koutsourakis; K. C. Kent Lloyd; Susan Marschall; Jeremy Mason; Colin McKerlie; Michael P. McLeod; Harald Von Melchner; Mark Moore; Alejandro O. Mujica; Andras Nagy; Mikhail Nefedov; Lauryl M. Nutter; Guillaume Pavlovic; Jane L. Peterson; Jonathan Pollock; Ramiro Ramirez-Solis; Derrick E. Rancourt; Marcello Raspa; Jacques E. Remacle; Martin Ringwald; Barry Rosen; Nadia Rosenthal; Janet Rossant; Patricia Ruiz Noppinger; Ed Ryder; Joel Zupicich Schick; Frank Schnütgen; Paul Schofield; Claudia Seisenberger; Mohammed Selloum; Elizabeth M Simpson; William C Skarnes; Damian P Smedley; William L Stanford; A. Francis Stewart; Kevin Stone; Kate Swan; Hamsa Tadepally; Lydia Teboul; Glauco P. Tocchini-Valentini; David M Valenzuela; Anthony P. West; Ken Ichi Yamamura; Yuko Yoshinaga; Wolfgang Wurst

doi:10.1007/s00335-012-9422-2

The mammalian gene function resource: The International Knockout Mouse Consortium

Allan Bradley, Konstantinos Anastassiadis, Abdelkader Ayadi, James F. Battey, Cindy Bell, Marie Christine Birling, Joanna R Bottomley, Steve D. Brown, Antje Bürger, Carol J. Bult, Wendy Bushell, Francis S. Collins, Christian Desaintes, Brendan Doe, Economides Aris, Janan T. Eppig, Richard H. Finnell, Colin Fletcher, Martin Fray, David FrendeweyRoland H. Friedel, Frank G. Grosveld, Jens Hansen, Yann Hérault, Geoffrey Hicks, Andreas Hörlein, Richard Houghton, Martin Hrabé De Angelis, Danny Huylebroeck, Vivek Iyer, Pieter J. De Jong, James A. Kadin, Cornelia Kaloff, Karen Kennedy, Manousos Koutsourakis, K. C. Kent Lloyd, Susan Marschall, Jeremy Mason, Colin McKerlie, Michael P. McLeod, Harald Von Melchner, Mark Moore, Alejandro O. Mujica, Andras Nagy, Mikhail Nefedov, Lauryl M. Nutter, Guillaume Pavlovic, Jane L. Peterson, Jonathan Pollock, Ramiro Ramirez-Solis, Derrick E. Rancourt, Marcello Raspa, Jacques E. Remacle, Martin Ringwald, Barry Rosen, Nadia Rosenthal, Janet Rossant, Patricia Ruiz Noppinger, Ed Ryder, Joel Zupicich Schick, Frank Schnütgen, Paul Schofield, Claudia Seisenberger, Mohammed Selloum, Elizabeth M Simpson, William C Skarnes, Damian P Smedley, William L Stanford, A. Francis Stewart, Kevin Stone, Kate Swan, Hamsa Tadepally, Lydia Teboul, Glauco P. Tocchini-Valentini, David M Valenzuela, Anthony P. West, Ken Ichi Yamamura, Yuko Yoshinaga, Wolfgang Wurst

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Abstract

In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed highthroughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Original language	English
Pages (from-to)	580-586
Number of pages	7
Journal	Mammalian Genome
Volume	23
Issue number	9-10
DOIs	https://doi.org/10.1007/s00335-012-9422-2
Publication status	Published - Oct 2012
Externally published	Yes

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Bradley, A., Anastassiadis, K., Ayadi, A., Battey, J. F., Bell, C., Birling, M. C., Bottomley, J. R., Brown, S. D., Bürger, A., Bult, C. J., Bushell, W., Collins, F. S., Desaintes, C., Doe, B., Aris, E., Eppig, J. T., Finnell, R. H., Fletcher, C., Fray, M., ... Wurst, W. (2012). The mammalian gene function resource: The International Knockout Mouse Consortium. Mammalian Genome, 23(9-10), 580-586. https://doi.org/10.1007/s00335-012-9422-2

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title = "The mammalian gene function resource: The International Knockout Mouse Consortium",

abstract = "In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed highthroughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.",

author = "Allan Bradley and Konstantinos Anastassiadis and Abdelkader Ayadi and Battey, {James F.} and Cindy Bell and Birling, {Marie Christine} and Bottomley, {Joanna R} and Brown, {Steve D.} and Antje B{\"u}rger and Bult, {Carol J.} and Wendy Bushell and Collins, {Francis S.} and Christian Desaintes and Brendan Doe and Economides Aris and Eppig, {Janan T.} and Finnell, {Richard H.} and Colin Fletcher and Martin Fray and David Frendewey and Friedel, {Roland H.} and Grosveld, {Frank G.} and Jens Hansen and Yann H{\'e}rault and Geoffrey Hicks and Andreas H{\"o}rlein and Richard Houghton and {Hrab{\'e} De Angelis}, Martin and Danny Huylebroeck and Vivek Iyer and {De Jong}, {Pieter J.} and Kadin, {James A.} and Cornelia Kaloff and Karen Kennedy and Manousos Koutsourakis and {Kent Lloyd}, {K. C.} and Susan Marschall and Jeremy Mason and Colin McKerlie and McLeod, {Michael P.} and {Von Melchner}, Harald and Mark Moore and Mujica, {Alejandro O.} and Andras Nagy and Mikhail Nefedov and Nutter, {Lauryl M.} and Guillaume Pavlovic and Peterson, {Jane L.} and Jonathan Pollock and Ramiro Ramirez-Solis and Rancourt, {Derrick E.} and Marcello Raspa and Remacle, {Jacques E.} and Martin Ringwald and Barry Rosen and Nadia Rosenthal and Janet Rossant and {Ruiz Noppinger}, Patricia and Ed Ryder and Schick, {Joel Zupicich} and Frank Schn{\"u}tgen and Paul Schofield and Claudia Seisenberger and Mohammed Selloum and Simpson, {Elizabeth M} and Skarnes, {William C} and Smedley, {Damian P} and Stanford, {William L} and {Francis Stewart}, A. and Kevin Stone and Kate Swan and Hamsa Tadepally and Lydia Teboul and Tocchini-Valentini, {Glauco P.} and Valenzuela, {David M} and West, {Anthony P.} and Yamamura, {Ken Ichi} and Yuko Yoshinaga and Wolfgang Wurst",

year = "2012",

month = oct,

doi = "10.1007/s00335-012-9422-2",

language = "English",

volume = "23",

pages = "580--586",

journal = "Mammalian Genome",

issn = "0938-8990",

publisher = "Springer-Verlag London Ltd.",

number = "9-10",

}

Bradley, A, Anastassiadis, K, Ayadi, A, Battey, JF, Bell, C, Birling, MC, Bottomley, JR, Brown, SD, Bürger, A, Bult, CJ, Bushell, W, Collins, FS, Desaintes, C, Doe, B, Aris, E, Eppig, JT, Finnell, RH, Fletcher, C, Fray, M, Frendewey, D, Friedel, RH, Grosveld, FG, Hansen, J, Hérault, Y, Hicks, G, Hörlein, A, Houghton, R, Hrabé De Angelis, M, Huylebroeck, D, Iyer, V, De Jong, PJ, Kadin, JA, Kaloff, C, Kennedy, K, Koutsourakis, M, Kent Lloyd, KC, Marschall, S, Mason, J, McKerlie, C, McLeod, MP, Von Melchner, H, Moore, M, Mujica, AO, Nagy, A, Nefedov, M, Nutter, LM, Pavlovic, G, Peterson, JL, Pollock, J, Ramirez-Solis, R, Rancourt, DE, Raspa, M, Remacle, JE, Ringwald, M, Rosen, B, Rosenthal, N, Rossant, J, Ruiz Noppinger, P, Ryder, E, Schick, JZ, Schnütgen, F, Schofield, P, Seisenberger, C, Selloum, M, Simpson, EM, Skarnes, WC, Smedley, DP, Stanford, WL, Francis Stewart, A, Stone, K, Swan, K, Tadepally, H, Teboul, L, Tocchini-Valentini, GP, Valenzuela, DM, West, AP, Yamamura, KI, Yoshinaga, Y & Wurst, W 2012, 'The mammalian gene function resource: The International Knockout Mouse Consortium', Mammalian Genome, vol. 23, no. 9-10, pp. 580-586. https://doi.org/10.1007/s00335-012-9422-2

TY - JOUR

T1 - The mammalian gene function resource

T2 - The International Knockout Mouse Consortium

AU - Bradley, Allan

AU - Anastassiadis, Konstantinos

AU - Ayadi, Abdelkader

AU - Battey, James F.

AU - Bell, Cindy

AU - Birling, Marie Christine

AU - Bottomley, Joanna R

AU - Brown, Steve D.

AU - Bürger, Antje

AU - Bult, Carol J.

AU - Bushell, Wendy

AU - Collins, Francis S.

AU - Desaintes, Christian

AU - Doe, Brendan

AU - Aris, Economides

AU - Eppig, Janan T.

AU - Finnell, Richard H.

AU - Fletcher, Colin

AU - Fray, Martin

AU - Frendewey, David

AU - Friedel, Roland H.

AU - Grosveld, Frank G.

AU - Hansen, Jens

AU - Hérault, Yann

AU - Hicks, Geoffrey

AU - Hörlein, Andreas

AU - Houghton, Richard

AU - Hrabé De Angelis, Martin

AU - Huylebroeck, Danny

AU - Iyer, Vivek

AU - De Jong, Pieter J.

AU - Kadin, James A.

AU - Kaloff, Cornelia

AU - Kennedy, Karen

AU - Koutsourakis, Manousos

AU - Kent Lloyd, K. C.

AU - Marschall, Susan

AU - Mason, Jeremy

AU - McKerlie, Colin

AU - McLeod, Michael P.

AU - Von Melchner, Harald

AU - Moore, Mark

AU - Mujica, Alejandro O.

AU - Nagy, Andras

AU - Nefedov, Mikhail

AU - Nutter, Lauryl M.

AU - Pavlovic, Guillaume

AU - Peterson, Jane L.

AU - Pollock, Jonathan

AU - Ramirez-Solis, Ramiro

AU - Rancourt, Derrick E.

AU - Raspa, Marcello

AU - Remacle, Jacques E.

AU - Ringwald, Martin

AU - Rosen, Barry

AU - Rosenthal, Nadia

AU - Rossant, Janet

AU - Ruiz Noppinger, Patricia

AU - Ryder, Ed

AU - Schick, Joel Zupicich

AU - Schnütgen, Frank

AU - Schofield, Paul

AU - Seisenberger, Claudia

AU - Selloum, Mohammed

AU - Simpson, Elizabeth M

AU - Skarnes, William C

AU - Smedley, Damian P

AU - Stanford, William L

AU - Francis Stewart, A.

AU - Stone, Kevin

AU - Swan, Kate

AU - Tadepally, Hamsa

AU - Teboul, Lydia

AU - Tocchini-Valentini, Glauco P.

AU - Valenzuela, David M

AU - West, Anthony P.

AU - Yamamura, Ken Ichi

AU - Yoshinaga, Yuko

AU - Wurst, Wolfgang

PY - 2012/10

Y1 - 2012/10

N2 - In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed highthroughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

AB - In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed highthroughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

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U2 - 10.1007/s00335-012-9422-2

DO - 10.1007/s00335-012-9422-2

M3 - Article

C2 - 22968824

AN - SCOPUS:84867332476

SN - 0938-8990

VL - 23

SP - 580

EP - 586

JO - Mammalian Genome

JF - Mammalian Genome

IS - 9-10

ER -

The mammalian gene function resource: The International Knockout Mouse Consortium

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