The MAM Study: A clinical study of milk allergy mechanisms in adults

R. G. Crittenden, C. H. Little, G. M. Georgiou, S. R. Forsyth, L. E. Bennett

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Abstract

The predominant mechanism of cow's milk allergy (CMA) differs in adults from the classical IgE-mediated allergy mechanisms commonly seen in infants and children. In adults, CMA usually does not involve the antibody IgE, but rather non-lgE-mediated inflammatory processes. Unfortunately, the precise mechanisms of non-lgE mediated reactions remain unclear, which has hindered the development of diagnostics, potential therapeutics and laboratory tools to aid the development of hypoallergenic dairy products for adults. The Milk Allergy Mechanisms (MAM) Study is a pilot clinical trial to investigate the immunopathological mechanisms of non-lgE-mediated CMA in adults. This paper presents preliminary data that indicate that CMA in adults is associated with Th1 cell activity. Analysis of a range of milk protein-specific antibody classes suggests that serum antibody titres are not useful in diagnosing adult CMA.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalAustralian Journal of Dairy Technology
Volume60
Issue number2 SPEC. ISS.
Publication statusPublished - 1 Jul 2005
Externally publishedYes

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