The makings of maleness: towards an integrated view of male sexual development

Dagmar Wilhelm, Peter A Koopman

Research output: Contribution to journalArticleResearchpeer-review

168 Citations (Scopus)


As the mammalian embryo develops, it must engage one of the two distinct programmes of gene activity, morphogenesis and organogenesis that characterize males and females. In males, sexual development hinges on testis determination and differentiation, but also involves many coordinated transcriptional, signalling and endocrine networks that underpin the masculinization of other organs and tissues, including the brain. Here we bring together current knowledge about these networks, identify gaps in the overall picture, and highlight the known defects that lead to disorders of male sexual development.
Original languageEnglish
Pages (from-to)620 - 631
Number of pages12
JournalNature Reviews Genetics
Issue number8
Publication statusPublished - 2006
Externally publishedYes

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