Abstract
Testicular macrophages are the largest leukocyte population in the testis. Their environment is characterized by the seemingly contradictory needs for tolerance against the autoantigenic germ cells and the capacity to mount pro-inflammatory innate immune responses against invading pathogens. During the past years considerable progress has been made in our understanding how intracellular signaling events enable testicular macrophages to adequately respond to inflammatory stimuli with the capacity to clear pathogens, but avoid excessive tissue damage to maintain fertility. Moreover, new data add to our understanding that testicular macrophages play essential roles in normal testis homeostasis and fetal testicular development.
| Original language | English |
|---|---|
| Pages (from-to) | 107-112 |
| Number of pages | 6 |
| Journal | Journal of Reproductive Immunology |
| Volume | 119 |
| DOIs | |
| Publication status | Published - 1 Feb 2017 |
| Externally published | Yes |
Cite this
}
The macrophages in testis function. / Bhushan, Sudhanshu; Meinhardt, Andreas.
In: Journal of Reproductive Immunology, Vol. 119, 01.02.2017, p. 107-112.Research output: Contribution to journal › Short Survey › Research › peer-review
TY - JOUR
T1 - The macrophages in testis function
AU - Bhushan, Sudhanshu
AU - Meinhardt, Andreas
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Testicular macrophages are the largest leukocyte population in the testis. Their environment is characterized by the seemingly contradictory needs for tolerance against the autoantigenic germ cells and the capacity to mount pro-inflammatory innate immune responses against invading pathogens. During the past years considerable progress has been made in our understanding how intracellular signaling events enable testicular macrophages to adequately respond to inflammatory stimuli with the capacity to clear pathogens, but avoid excessive tissue damage to maintain fertility. Moreover, new data add to our understanding that testicular macrophages play essential roles in normal testis homeostasis and fetal testicular development.
AB - Testicular macrophages are the largest leukocyte population in the testis. Their environment is characterized by the seemingly contradictory needs for tolerance against the autoantigenic germ cells and the capacity to mount pro-inflammatory innate immune responses against invading pathogens. During the past years considerable progress has been made in our understanding how intracellular signaling events enable testicular macrophages to adequately respond to inflammatory stimuli with the capacity to clear pathogens, but avoid excessive tissue damage to maintain fertility. Moreover, new data add to our understanding that testicular macrophages play essential roles in normal testis homeostasis and fetal testicular development.
UR - http://www.scopus.com/inward/record.url?scp=85013178226&partnerID=8YFLogxK
U2 - 10.1016/j.jri.2016.06.008
DO - 10.1016/j.jri.2016.06.008
M3 - Short Survey
VL - 119
SP - 107
EP - 112
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
SN - 0165-0378
ER -