TY - JOUR
T1 - The Longitudinal Effects of Persistent Apnea on Cerebral Oxygenation in Infants Born Preterm
AU - Horne, Rosemary S. C.
AU - Fung, Annie C. H.
AU - McNeil, Scott
AU - Fyfe, Karinna L.
AU - Odoi, Alexsandria
AU - Wong, Flora Y.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Objective To assess the incidence and impact of persistent apnea on heart rate (HR), oxygen saturation (SpO2), and brain tissue oxygenation index (TOI) over the first 6 months after term equivalent age in ex-preterm infants. Study design Twenty-four preterm infants born between 27 and 36 weeks of gestational age were studied with daytime polysomnography at 2-4 weeks, 2-3 months, and 5-6 months post-term corrected age. Apneas lasting ≥3 seconds were included and maximal percentage changes (nadir) in HR, SpO2 and tissue oxygenation index (TOI, NIRO-200 Hamamatsu) from baseline were analyzed. Results A total of 253 apneas were recorded at 2-4 weeks, 203 at 2-3 months, and 148 at 5-6 months. There was no effect of gestational age at birth, sleep state, or sleep position on apnea duration, nadir HR, SpO2, or TOI. At 2-4 weeks, the nadirs in HR (−11.1 ± 1.2 bpm) and TOI (−4.4 ± 1.0%) were significantly less than at 2-3 months (HR: −13.5 ± 1.2 bpm, P < .05; TOI: −7.5 ± 1.1 %, P < .05) and at 5-6 months (HR: −13.2 ± 1.3 bpm, P < .01; TOI: −9.3 ± 1.2%, P < .01). Conclusions In ex-preterm infants, apneas were frequent and associated with decreases in heart rate and cerebral oxygenation, which were more marked at 2-3 months and 5-6 months than at 2-4 weeks. Although events were short, they may contribute to the adverse neurocognitive outcomes that are common in ex-preterm children.
AB - Objective To assess the incidence and impact of persistent apnea on heart rate (HR), oxygen saturation (SpO2), and brain tissue oxygenation index (TOI) over the first 6 months after term equivalent age in ex-preterm infants. Study design Twenty-four preterm infants born between 27 and 36 weeks of gestational age were studied with daytime polysomnography at 2-4 weeks, 2-3 months, and 5-6 months post-term corrected age. Apneas lasting ≥3 seconds were included and maximal percentage changes (nadir) in HR, SpO2 and tissue oxygenation index (TOI, NIRO-200 Hamamatsu) from baseline were analyzed. Results A total of 253 apneas were recorded at 2-4 weeks, 203 at 2-3 months, and 148 at 5-6 months. There was no effect of gestational age at birth, sleep state, or sleep position on apnea duration, nadir HR, SpO2, or TOI. At 2-4 weeks, the nadirs in HR (−11.1 ± 1.2 bpm) and TOI (−4.4 ± 1.0%) were significantly less than at 2-3 months (HR: −13.5 ± 1.2 bpm, P < .05; TOI: −7.5 ± 1.1 %, P < .05) and at 5-6 months (HR: −13.2 ± 1.3 bpm, P < .01; TOI: −9.3 ± 1.2%, P < .01). Conclusions In ex-preterm infants, apneas were frequent and associated with decreases in heart rate and cerebral oxygenation, which were more marked at 2-3 months and 5-6 months than at 2-4 weeks. Although events were short, they may contribute to the adverse neurocognitive outcomes that are common in ex-preterm children.
KW - apnea
KW - preterm
KW - sleep
KW - sleeping position
UR - http://www.scopus.com/inward/record.url?scp=85008517573&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2016.11.081
DO - 10.1016/j.jpeds.2016.11.081
M3 - Article
AN - SCOPUS:85008517573
VL - 182
SP - 79
EP - 84
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
ER -