The location of white matter lesions and gait-A voxel-based study

Velandai Srikanth, Thanh G Phan, Jian Chen, Richard Beare, Jennifer Maree Stapleton, David Charles Reutens

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Little is known about the influence of cerebral white matter lesion (WML) location on gait. We applied partial least squares regression in brain magnetic resonance imaging scans (n = 385) to evaluate which WML voxel systems were independently associated with a composite gait score and identified affected tracts using a diffusion tensor imaging template. Bilateral frontal and periventricular WML-affected voxels corresponding to major anterior projection fibers (thalamic radiations, corticofugal motor tracts) and adjacent association fibers (corpus callosum, superior fronto-occipital fasciculus, short association fibers) showed the greatest covariance with poorer gait. WMLs probably contribute to age-related gait decline by disconnecting motor networks served by these tracts.
Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalAnnals of Neurology
Issue number2
Publication statusPublished - 2010

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