The location of Australian Buruli ulcer lesions—Implications for unravelling disease transmission

Arvind Yerramilli, Ee Laine Tay, Andrew J. Stewardson, Peter G Kelley, Emma Bishop, Grant A. Jenkin, Mike Starr, Janine Trevillyan, Andrew Hughes, N Deborah Friedman, Daniel P. O’Brien, Paul D.R. Johnson

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Background: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. Methods: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998–2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection. Findings: We examined 579 patients with 649 lesions; 32 (5.5%) patients had multiple lesions. Lesions were predominantly located on lower (70.0%) and upper (27.1%) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95% CI 1·38–2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95% CI 0·34–0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95% CI 1·52–6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95% CI 1·14–5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3%) were likely acquired in the warmer 6 months of the year. Interpretation: Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission.

Original languageEnglish
Article numbere0005800
Number of pages16
JournalPLoS Neglected Tropical Diseases
Volume11
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017
Externally publishedYes

Cite this

Yerramilli, Arvind ; Tay, Ee Laine ; Stewardson, Andrew J. ; Kelley, Peter G ; Bishop, Emma ; Jenkin, Grant A. ; Starr, Mike ; Trevillyan, Janine ; Hughes, Andrew ; Friedman, N Deborah ; O’Brien, Daniel P. ; Johnson, Paul D.R. / The location of Australian Buruli ulcer lesions—Implications for unravelling disease transmission. In: PLoS Neglected Tropical Diseases. 2017 ; Vol. 11, No. 8.
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title = "The location of Australian Buruli ulcer lesions—Implications for unravelling disease transmission",
abstract = "Background: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. Methods: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998–2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection. Findings: We examined 579 patients with 649 lesions; 32 (5.5{\%}) patients had multiple lesions. Lesions were predominantly located on lower (70.0{\%}) and upper (27.1{\%}) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95{\%} CI 1·38–2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95{\%} CI 0·34–0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95{\%} CI 1·52–6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95{\%} CI 1·14–5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3{\%}) were likely acquired in the warmer 6 months of the year. Interpretation: Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission.",
author = "Arvind Yerramilli and Tay, {Ee Laine} and Stewardson, {Andrew J.} and Kelley, {Peter G} and Emma Bishop and Jenkin, {Grant A.} and Mike Starr and Janine Trevillyan and Andrew Hughes and Friedman, {N Deborah} and O’Brien, {Daniel P.} and Johnson, {Paul D.R.}",
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Yerramilli, A, Tay, EL, Stewardson, AJ, Kelley, PG, Bishop, E, Jenkin, GA, Starr, M, Trevillyan, J, Hughes, A, Friedman, ND, O’Brien, DP & Johnson, PDR 2017, 'The location of Australian Buruli ulcer lesions—Implications for unravelling disease transmission', PLoS Neglected Tropical Diseases, vol. 11, no. 8, e0005800. https://doi.org/10.1371/journal.pntd.0005800

The location of Australian Buruli ulcer lesions—Implications for unravelling disease transmission. / Yerramilli, Arvind; Tay, Ee Laine; Stewardson, Andrew J.; Kelley, Peter G; Bishop, Emma; Jenkin, Grant A.; Starr, Mike; Trevillyan, Janine; Hughes, Andrew; Friedman, N Deborah; O’Brien, Daniel P.; Johnson, Paul D.R.

In: PLoS Neglected Tropical Diseases, Vol. 11, No. 8, e0005800, 01.08.2017.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The location of Australian Buruli ulcer lesions—Implications for unravelling disease transmission

AU - Yerramilli, Arvind

AU - Tay, Ee Laine

AU - Stewardson, Andrew J.

AU - Kelley, Peter G

AU - Bishop, Emma

AU - Jenkin, Grant A.

AU - Starr, Mike

AU - Trevillyan, Janine

AU - Hughes, Andrew

AU - Friedman, N Deborah

AU - O’Brien, Daniel P.

AU - Johnson, Paul D.R.

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N2 - Background: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. Methods: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998–2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection. Findings: We examined 579 patients with 649 lesions; 32 (5.5%) patients had multiple lesions. Lesions were predominantly located on lower (70.0%) and upper (27.1%) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95% CI 1·38–2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95% CI 0·34–0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95% CI 1·52–6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95% CI 1·14–5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3%) were likely acquired in the warmer 6 months of the year. Interpretation: Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission.

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