The aim of this study was to determine the effects of E2 (17 -estradiol) replacement, acyline (GnRH antagonist) and flutamide (anti-androgen) treatment on the ovarian phenotype of ArKO mice. E2 replacement and acyline treatment but not flutamide treatment, reduced serum gonadotrophin levels of ArKO mice to within normal ranges.
Liew, S. H., Drummond, A. E., Jones, M. E., & Findlay, J. K. (2010). The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype. Molecular and Cellular Endocrinology, 327(1-2), 56 - 64. https://doi.org/10.1016/j.mce.2010.05.003