The L6 membrane proteins - A new four-transmembrane superfamily

Mark D. Wright, Jian Ni, George B. Rudy

Research output: Contribution to journalReview ArticleResearchpeer-review

90 Citations (Scopus)


L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.

Original languageEnglish
Pages (from-to)1594-1600
Number of pages7
JournalProtein Science
Issue number8
Publication statusPublished - 1 Jan 2000
Externally publishedYes


  • L6
  • Superfamily
  • Tetraspanin

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