The L6 membrane proteins - A new four-transmembrane superfamily

Mark D. Wright; Jian Ni; George B. Rudy

doi:10.1110/ps.9.8.1594

The L6 membrane proteins - A new four-transmembrane superfamily

Mark D. Wright, Jian Ni, George B. Rudy

Research output: Contribution to journal › Review Article › Research › peer-review

105 Citations (Scopus)

Abstract

L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.

Original language	English
Pages (from-to)	1594-1600
Number of pages	7
Journal	Protein Science
Volume	9
Issue number	8
DOIs	https://doi.org/10.1110/ps.9.8.1594
Publication status	Published - 1 Jan 2000
Externally published	Yes

Keywords

L6
Superfamily
Tetraspanin

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10.1110/ps.9.8.1594

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abstract = "L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.",

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AU - Ni, Jian

AU - Rudy, George B.

PY - 2000/1/1

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N2 - L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.

AB - L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.

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KW - Superfamily

KW - Tetraspanin

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U2 - 10.1110/ps.9.8.1594

DO - 10.1110/ps.9.8.1594

M3 - Review Article

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AN - SCOPUS:0033842343

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VL - 9

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JO - Protein Science

JF - Protein Science

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ER -

The L6 membrane proteins - A new four-transmembrane superfamily

Abstract

Keywords

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