The Knockout Mouse Project

Christopher P. Austin, James F. Battey, Allan Bradley, Maja Bucan, Mario Capecchi, Francis S. Collins, William F. Dove, Geoffrey Duyk, Susan Dymecki, Janan T. Eppig, Franziska B. Grieder, Nathaniel Heintz, Geoff Hicks, Thomas R. Insel, Alexandra Joyner, Beverly H. Koller, K. C.Kent Lloyd, Terry Magnuson, Mark W. Moore, Andras Nagy & 21 others Jonathan D. Pollock, Allen D. Roses, Arthur T. Sands, Brian Seed, William C. Skarnes, Jay Snoddy, Philippe Soriano, David J. Stewart, Francis Stewart, Bruce Stillman, Harold Varmus, Lyuba Varticovski, Inder M. Verma, Thomas F. Vogt, Harald Von Melchner, Jan Witkowski, Richard P. Woychik, Wolfgang Wurst, George D. Yancopoulos, Stephen G. Young, Brian Zambrowicz

Research output: Contribution to journalComment / DebateResearchpeer-review

Abstract

Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.

Original languageEnglish
Pages (from-to)921-924
Number of pages4
JournalNature Genetics
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 2004
Externally publishedYes

Cite this

Austin, C. P., Battey, J. F., Bradley, A., Bucan, M., Capecchi, M., Collins, F. S., ... Zambrowicz, B. (2004). The Knockout Mouse Project. Nature Genetics, 36(9), 921-924. https://doi.org/10.1038/ng0904-921
Austin, Christopher P. ; Battey, James F. ; Bradley, Allan ; Bucan, Maja ; Capecchi, Mario ; Collins, Francis S. ; Dove, William F. ; Duyk, Geoffrey ; Dymecki, Susan ; Eppig, Janan T. ; Grieder, Franziska B. ; Heintz, Nathaniel ; Hicks, Geoff ; Insel, Thomas R. ; Joyner, Alexandra ; Koller, Beverly H. ; Lloyd, K. C.Kent ; Magnuson, Terry ; Moore, Mark W. ; Nagy, Andras ; Pollock, Jonathan D. ; Roses, Allen D. ; Sands, Arthur T. ; Seed, Brian ; Skarnes, William C. ; Snoddy, Jay ; Soriano, Philippe ; Stewart, David J. ; Stewart, Francis ; Stillman, Bruce ; Varmus, Harold ; Varticovski, Lyuba ; Verma, Inder M. ; Vogt, Thomas F. ; Von Melchner, Harald ; Witkowski, Jan ; Woychik, Richard P. ; Wurst, Wolfgang ; Yancopoulos, George D. ; Young, Stephen G. ; Zambrowicz, Brian. / The Knockout Mouse Project. In: Nature Genetics. 2004 ; Vol. 36, No. 9. pp. 921-924.
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Austin, CP, Battey, JF, Bradley, A, Bucan, M, Capecchi, M, Collins, FS, Dove, WF, Duyk, G, Dymecki, S, Eppig, JT, Grieder, FB, Heintz, N, Hicks, G, Insel, TR, Joyner, A, Koller, BH, Lloyd, KCK, Magnuson, T, Moore, MW, Nagy, A, Pollock, JD, Roses, AD, Sands, AT, Seed, B, Skarnes, WC, Snoddy, J, Soriano, P, Stewart, DJ, Stewart, F, Stillman, B, Varmus, H, Varticovski, L, Verma, IM, Vogt, TF, Von Melchner, H, Witkowski, J, Woychik, RP, Wurst, W, Yancopoulos, GD, Young, SG & Zambrowicz, B 2004, 'The Knockout Mouse Project' Nature Genetics, vol. 36, no. 9, pp. 921-924. https://doi.org/10.1038/ng0904-921

The Knockout Mouse Project. / Austin, Christopher P.; Battey, James F.; Bradley, Allan; Bucan, Maja; Capecchi, Mario; Collins, Francis S.; Dove, William F.; Duyk, Geoffrey; Dymecki, Susan; Eppig, Janan T.; Grieder, Franziska B.; Heintz, Nathaniel; Hicks, Geoff; Insel, Thomas R.; Joyner, Alexandra; Koller, Beverly H.; Lloyd, K. C.Kent; Magnuson, Terry; Moore, Mark W.; Nagy, Andras; Pollock, Jonathan D.; Roses, Allen D.; Sands, Arthur T.; Seed, Brian; Skarnes, William C.; Snoddy, Jay; Soriano, Philippe; Stewart, David J.; Stewart, Francis; Stillman, Bruce; Varmus, Harold; Varticovski, Lyuba; Verma, Inder M.; Vogt, Thomas F.; Von Melchner, Harald; Witkowski, Jan; Woychik, Richard P.; Wurst, Wolfgang; Yancopoulos, George D.; Young, Stephen G.; Zambrowicz, Brian.

In: Nature Genetics, Vol. 36, No. 9, 09.2004, p. 921-924.

Research output: Contribution to journalComment / DebateResearchpeer-review

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AU - Austin, Christopher P.

AU - Battey, James F.

AU - Bradley, Allan

AU - Bucan, Maja

AU - Capecchi, Mario

AU - Collins, Francis S.

AU - Dove, William F.

AU - Duyk, Geoffrey

AU - Dymecki, Susan

AU - Eppig, Janan T.

AU - Grieder, Franziska B.

AU - Heintz, Nathaniel

AU - Hicks, Geoff

AU - Insel, Thomas R.

AU - Joyner, Alexandra

AU - Koller, Beverly H.

AU - Lloyd, K. C.Kent

AU - Magnuson, Terry

AU - Moore, Mark W.

AU - Nagy, Andras

AU - Pollock, Jonathan D.

AU - Roses, Allen D.

AU - Sands, Arthur T.

AU - Seed, Brian

AU - Skarnes, William C.

AU - Snoddy, Jay

AU - Soriano, Philippe

AU - Stewart, David J.

AU - Stewart, Francis

AU - Stillman, Bruce

AU - Varmus, Harold

AU - Varticovski, Lyuba

AU - Verma, Inder M.

AU - Vogt, Thomas F.

AU - Von Melchner, Harald

AU - Witkowski, Jan

AU - Woychik, Richard P.

AU - Wurst, Wolfgang

AU - Yancopoulos, George D.

AU - Young, Stephen G.

AU - Zambrowicz, Brian

PY - 2004/9

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AB - Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.

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JO - Nature Genetics

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Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS et al. The Knockout Mouse Project. Nature Genetics. 2004 Sep;36(9):921-924. https://doi.org/10.1038/ng0904-921