The Knockout Mouse Project

Christopher P. Austin, James F. Battey, Allan Bradley, Maja Bucan, Mario Capecchi, Francis S. Collins, William F. Dove, Geoffrey Duyk, Susan Dymecki, Janan T. Eppig, Franziska B. Grieder, Nathaniel Heintz, Geoff Hicks, Thomas R. Insel, Alexandra Joyner, Beverly H. Koller, K. C.Kent Lloyd, Terry Magnuson, Mark W. Moore, Andras NagyJonathan D. Pollock, Allen D. Roses, Arthur T. Sands, Brian Seed, William C. Skarnes, Jay Snoddy, Philippe Soriano, David J. Stewart, Francis Stewart, Bruce Stillman, Harold Varmus, Lyuba Varticovski, Inder M. Verma, Thomas F. Vogt, Harald Von Melchner, Jan Witkowski, Richard P. Woychik, Wolfgang Wurst, George D. Yancopoulos, Stephen G. Young, Brian Zambrowicz

Research output: Contribution to journalComment / DebateResearchpeer-review

518 Citations (Scopus)


Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.

Original languageEnglish
Pages (from-to)921-924
Number of pages4
JournalNature Genetics
Issue number9
Publication statusPublished - Sept 2004
Externally publishedYes

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