TY - JOUR
T1 - The kinomes of apicomplexan parasites
AU - Miranda-Saavedra, Diego
AU - Gabaldon, Toni
AU - Barton, Geoffrey J
AU - Langsley, Gordon
AU - Doerig, Christian D
PY - 2012
Y1 - 2012
N2 - Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.
AB - Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22587893
U2 - 10.1016/j.micinf.2012.04.007
DO - 10.1016/j.micinf.2012.04.007
M3 - Article
SN - 1286-4579
VL - 14
SP - 796
EP - 810
JO - Microbes and Infection
JF - Microbes and Infection
IS - 10
ER -