The kinomes of apicomplexan parasites

Diego Miranda-Saavedra, Toni Gabaldon, Geoffrey J Barton, Gordon Langsley, Christian D Doerig

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Abstract

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.
Original languageEnglish
Pages (from-to)796 - 810
Number of pages15
JournalMicrobes and Infection
Volume14
Issue number10
DOIs
Publication statusPublished - 2012

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