The kinome 'at large' in cancer

Emmy D. G. Fleuren; Luxi Zhang; Jianmin Wu; Roger J. Daly

doi:10.1038/nrc.2015.18

The kinome 'at large' in cancer

Emmy D. G. Fleuren, Luxi Zhang, Jianmin Wu, Roger J. Daly

Research output: Contribution to journal › Article › Research › peer-review

221 Citations (Scopus)

Abstract

Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome at large in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.

Original language	English
Pages (from-to)	83-98
Number of pages	16
Journal	Nature Reviews Cancer
Volume	16
Issue number	2
DOIs	https://doi.org/10.1038/nrc.2015.18
Publication status	Published - Feb 2016

Keywords

cancer genomics
functional genomics
kinases
oncogenes
phosphorylation
proteomics
systems biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc.2015.18

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title = "The kinome 'at large' in cancer",

abstract = "Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome at large in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.",

keywords = "cancer genomics, functional genomics, kinases, oncogenes, phosphorylation, proteomics, systems biology",

author = "Fleuren, {Emmy D. G.} and Luxi Zhang and Jianmin Wu and Daly, {Roger J.}",

year = "2016",

month = feb,

doi = "10.1038/nrc.2015.18",

language = "English",

volume = "16",

pages = "83--98",

journal = "Nature Reviews Cancer",

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T1 - The kinome 'at large' in cancer

AU - Fleuren, Emmy D. G.

AU - Zhang, Luxi

AU - Wu, Jianmin

AU - Daly, Roger J.

PY - 2016/2

Y1 - 2016/2

N2 - Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome at large in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.

AB - Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome at large in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.

KW - cancer genomics

KW - functional genomics

KW - kinases

KW - oncogenes

KW - phosphorylation

KW - proteomics

KW - systems biology

UR - http://www.ncbi.nlm.nih.gov/pubmed/26822576

U2 - 10.1038/nrc.2015.18

DO - 10.1038/nrc.2015.18

M3 - Article

SN - 1474-175X

VL - 16

SP - 83

EP - 98

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 2

ER -

The kinome 'at large' in cancer

Abstract

Keywords

UN SDGs

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NHMRC Research Fellowship

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The kinome 'at large' in cancer

Abstract

Keywords

UN SDGs

Access to Document

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Projects

NHMRC Research Fellowship

Cite this