The kinome 'at large' in cancer

Emmy D. G. Fleuren, Luxi Zhang, Jianmin Wu, Roger J. Daly

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

Abstract

Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome at large in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.
Original languageEnglish
Pages (from-to)83-98
Number of pages16
JournalNature Reviews Cancer
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 2016

Keywords

  • cancer genomics
  • functional genomics
  • kinases
  • oncogenes
  • phosphorylation
  • proteomics
  • systems biology

Cite this