Projects per year
Abstract
Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.
Original language | English |
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Pages (from-to) | 3002-3015 |
Number of pages | 14 |
Journal | The FEBS Journal |
DOIs | |
Publication status | Published - 1 Aug 2016 |
Keywords
- adipose tissue
- brain
- cytokines
- diabetes
- hormones
- JAK/STAT signaling pathway
- liver
- muscle
- obesity
- pancreas
Projects
- 1 Finished
-
In vivo and biochemical appraisal of mitochondrial STAT3
Gough, D. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/17
Project: Research