The JAK/STAT pathway in obesity and diabetes

Esteban N. Gurzov; William J Stanley; Evan G. Pappas; Helen E Thomas; Daniel J. Gough

doi:10.1111/febs.13709

The JAK/STAT pathway in obesity and diabetes

Esteban N. Gurzov, William J Stanley, Evan G. Pappas, Helen E Thomas, Daniel J. Gough

Hudson Institute - Department of Molecular and Translational Science

Research output: Contribution to journal › Review Article › Other › peer-review

210 Citations (Scopus)

Abstract

Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.

Original language	English
Pages (from-to)	3002-3015
Number of pages	14
Journal	The FEBS Journal
DOIs	https://doi.org/10.1111/febs.13709
Publication status	Published - 1 Aug 2016

Keywords

adipose tissue
brain
cytokines
diabetes
hormones
JAK/STAT signaling pathway
liver
muscle
obesity
pancreas

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/febs.13709

Cite this

@article{6a6fc3162deb49138e1da347a1a7c7e3,

title = "The JAK/STAT pathway in obesity and diabetes",

abstract = "Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.",

keywords = "adipose tissue, brain, cytokines, diabetes, hormones, JAK/STAT signaling pathway, liver, muscle, obesity, pancreas",

author = "Gurzov, {Esteban N.} and Stanley, {William J} and Pappas, {Evan G.} and Thomas, {Helen E} and Gough, {Daniel J.}",

year = "2016",

month = aug,

day = "1",

doi = "10.1111/febs.13709",

language = "English",

pages = "3002--3015",

journal = "The FEBS Journal",

issn = "1742-464X",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - The JAK/STAT pathway in obesity and diabetes

AU - Gurzov, Esteban N.

AU - Stanley, William J

AU - Pappas, Evan G.

AU - Thomas, Helen E

AU - Gough, Daniel J.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.

AB - Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.

KW - adipose tissue

KW - brain

KW - cytokines

KW - diabetes

KW - hormones

KW - JAK/STAT signaling pathway

KW - liver

KW - muscle

KW - obesity

KW - pancreas

UR - http://www.scopus.com/inward/record.url?scp=84983294413&partnerID=8YFLogxK

U2 - 10.1111/febs.13709

DO - 10.1111/febs.13709

M3 - Review Article

C2 - 26972840

AN - SCOPUS:84983294413

SN - 1742-464X

SP - 3002

EP - 3015

JO - The FEBS Journal

JF - The FEBS Journal

ER -

The JAK/STAT pathway in obesity and diabetes

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

In vivo and biochemical appraisal of mitochondrial STAT3

Cite this

The JAK/STAT pathway in obesity and diabetes

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

In vivo and biochemical appraisal of mitochondrial STAT3

Cite this