The JAK/STAT pathway in obesity and diabetes

Esteban N. Gurzov, William J Stanley, Evan G. Pappas, Helen E Thomas, Daniel J. Gough

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48 Citations (Scopus)

Abstract

Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.

Original languageEnglish
Pages (from-to)3002-3015
Number of pages14
JournalFEBS Journal
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • adipose tissue
  • brain
  • cytokines
  • diabetes
  • hormones
  • JAK/STAT signaling pathway
  • liver
  • muscle
  • obesity
  • pancreas

Cite this

Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016). The JAK/STAT pathway in obesity and diabetes. FEBS Journal, 3002-3015. https://doi.org/10.1111/febs.13709