Abstract
Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 3002-3015 |
| Number of pages | 14 |
| Journal | FEBS Journal |
| DOIs | |
| Publication status | Published - 1 Aug 2016 |
Keywords
- adipose tissue
- brain
- cytokines
- diabetes
- hormones
- JAK/STAT signaling pathway
- liver
- muscle
- obesity
- pancreas
Cite this
}
The JAK/STAT pathway in obesity and diabetes. / Gurzov, Esteban N.; Stanley, William J; Pappas, Evan G.; Thomas, Helen E; Gough, Daniel J.
In: FEBS Journal, 01.08.2016, p. 3002-3015.Research output: Contribution to journal › Review Article › Other › peer-review
TY - JOUR
T1 - The JAK/STAT pathway in obesity and diabetes
AU - Gurzov, Esteban N.
AU - Stanley, William J
AU - Pappas, Evan G.
AU - Thomas, Helen E
AU - Gough, Daniel J.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.
AB - Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.
KW - adipose tissue
KW - brain
KW - cytokines
KW - diabetes
KW - hormones
KW - JAK/STAT signaling pathway
KW - liver
KW - muscle
KW - obesity
KW - pancreas
UR - http://www.scopus.com/inward/record.url?scp=84983294413&partnerID=8YFLogxK
U2 - 10.1111/febs.13709
DO - 10.1111/febs.13709
M3 - Review Article
SP - 3002
EP - 3015
JO - FEBS Journal
JF - FEBS Journal
SN - 1742-464X
ER -