TY - JOUR
T1 - The IUPHAR/BPS Guide to PHARMACOLOGY in 2018
T2 - Updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
AU - Harding, Simon D.
AU - Sharman, Joanna L.
AU - Faccenda, Elena
AU - Southan, Chris
AU - Pawson, Adam J.
AU - Ireland, Sam
AU - Gray, Alasdair J.G.
AU - Bruce, Liam
AU - Alexander, Stephen P.H.
AU - Anderton, Stephen
AU - Bryant, Clare
AU - Davenport, Anthony P.
AU - Doerig, Christian
AU - Fabbro, Doriano
AU - Levi-Schaffer, Francesca
AU - Spedding, Michael
AU - Davies, Jamie A.
AU - NC-IUPHAR
PY - 2018/1/4
Y1 - 2018/1/4
N2 - The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators. This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015. Our relationship matrix now describes 1/49000 ligands, 1/415 000 binding constants, 1/46000 papers and 1/41700 human proteins. As an important addition, we also introduce our newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). This has been 'forked' from the well-established GtoPdb data model and expanded into new types of data related to the immune system and inflammatory processes. This includes new ligands, targets, pathways, cell types and diseases for which we are recruiting new IUPHAR expert committees. Designed as an immunopharmacological gateway, it also has an emphasis on potential therapeutic interventions.
AB - The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators. This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015. Our relationship matrix now describes 1/49000 ligands, 1/415 000 binding constants, 1/46000 papers and 1/41700 human proteins. As an important addition, we also introduce our newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). This has been 'forked' from the well-established GtoPdb data model and expanded into new types of data related to the immune system and inflammatory processes. This includes new ligands, targets, pathways, cell types and diseases for which we are recruiting new IUPHAR expert committees. Designed as an immunopharmacological gateway, it also has an emphasis on potential therapeutic interventions.
UR - http://www.scopus.com/inward/record.url?scp=85040925105&partnerID=8YFLogxK
U2 - 10.1093/nar/gkx1121
DO - 10.1093/nar/gkx1121
M3 - Article
AN - SCOPUS:85040925105
SN - 0305-1048
VL - 46
SP - D1091-D1106
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -
