The involvement of tumor necrosis factor in immunity to Salmonella infection

John P. Tite, Gordon Dougan, Steven N. Chatfield

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91 Citations (Scopus)

Abstract

The role of TNF in immunity to Salmonella in mice was studied. Antiserum specific for murine TNF was raised and used to neutralize TNF activity in vivo. Injection of this serum into mice infected with the moderately mouse virulent Salmonella typhimurium strain M525 caused exacerbation of disease. Such treatment had no effect on the course of an infection with an attenuated S. typhimurium aroA (strain SL3261) mutant. However, the protection afforded by immunisation with live SL3261 against challenge with the virulent parent strain (SL1344) was abolished by anti-TNF antiserum. Interestingly both early (3 wk) immunity and late (10 wk) immunity was neutralized by such treatment. Inasmuch as early immunity is considered to be nonspecific and macrophage-mediated while late immunity is considered to be serotype-specific and T cell mediated, this suggests that TNF plays a role in protection from Salmonellosis in both cases.

Original languageEnglish
Pages (from-to)3161-3164
Number of pages4
JournalJournal of Immunology
Volume147
Issue number9
Publication statusPublished - 1 Nov 1991
Externally publishedYes

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