Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 3618 - 3635 |
| Number of pages | 18 |
| Journal | International Journal of Molecular Sciences |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 |
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The intriguing life of autophagosomes. / Mijaljica, Dalibor; Prescott, Mark; Devenish, Rodney J.
In: International Journal of Molecular Sciences, Vol. 13, No. 3, 2012, p. 3618 - 3635.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The intriguing life of autophagosomes
AU - Mijaljica, Dalibor
AU - Prescott, Mark
AU - Devenish, Rodney J
PY - 2012
Y1 - 2012
N2 - Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the macroautophagic process. Such events include exchange and flow of lipids and proteins between membranes and vesicles (e.g., during initiation and growth of the phagophore), vesicular positioning and trafficking within the cell (e.g., autophagosome location and movement) and fusion of autophagosomes with the boundary membranes of the degradative compartment. Here, we review current knowledge on the contribution of different organelles to the formation of autophagosomes, their trafficking and fate within the cell. We will consider some of the unresolved questions related to the molecular mechanisms that regulate the life and death of the autophagosome.
AB - Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the macroautophagic process. Such events include exchange and flow of lipids and proteins between membranes and vesicles (e.g., during initiation and growth of the phagophore), vesicular positioning and trafficking within the cell (e.g., autophagosome location and movement) and fusion of autophagosomes with the boundary membranes of the degradative compartment. Here, we review current knowledge on the contribution of different organelles to the formation of autophagosomes, their trafficking and fate within the cell. We will consider some of the unresolved questions related to the molecular mechanisms that regulate the life and death of the autophagosome.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22489171
U2 - 10.3390/ijms13033618
DO - 10.3390/ijms13033618
M3 - Article
VL - 13
SP - 3618
EP - 3635
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 3
ER -