The intriguing life of autophagosomes

Dalibor Mijaljica, Mark Prescott, Rodney J Devenish

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the macroautophagic process. Such events include exchange and flow of lipids and proteins between membranes and vesicles (e.g., during initiation and growth of the phagophore), vesicular positioning and trafficking within the cell (e.g., autophagosome location and movement) and fusion of autophagosomes with the boundary membranes of the degradative compartment. Here, we review current knowledge on the contribution of different organelles to the formation of autophagosomes, their trafficking and fate within the cell. We will consider some of the unresolved questions related to the molecular mechanisms that regulate the life and death of the autophagosome.
Original languageEnglish
Pages (from-to)3618 - 3635
Number of pages18
JournalInternational Journal of Molecular Sciences
Volume13
Issue number3
DOIs
Publication statusPublished - 2012

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