The intricacy of nuclear membrane dynamics during nucleophagy

Dalibor Mijaljica, Mark Prescott, Rodney J Devenish

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Abstract

The cell nucleus is an organelle bounded by a doublemembrane which undergoes drastic reorganization during major cellular events such as cell division and apoptosis. Maintenance of proper nuclear structure, function and dynamics is central to organelle vitality. Over recent years growing evidence has shown that parts of the nucleus can be specifically degraded by an autophagic process termed nucleophagy. The process is best described in the yeast, Saccharomyces cerevisiae, where piecemeal microautophagy of the nucleus or nucleophagy (micronucleophagy) requires direct interaction of the nuclear membrane with that of the vacuole (the yeast lytic compartment). Here, we review the process of nucleophagy in the context of nuclear membrane dynamics, and examine the evidence for autophagic degradation of the nucleus in mammalian cells. Finally, we discuss the importance of nucleophagy as a a??housecleaninga?? mechanism for the nucleus under both normal and disease conditions.
Original languageEnglish
Pages (from-to)213 - 223
Number of pages11
JournalNucleus
Volume1
Issue number3
DOIs
Publication statusPublished - 2010

Cite this