Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 531-537 |
| Number of pages | 7 |
| Journal | Nature Immunology |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2016 |
Keywords
- antigen processing and presentation
- innate immune cells
Cite this
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The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1. / McWilliam, Hamish E G; Eckle, Sidonia B G; Theodossis, Alex; Liu, Ligong; Chen, Zhenjun; Wubben, Jacinta M; Fairlie, David P; Strugnell, Richard A; Mintern, Justine D; McCluskey, James; Rossjohn, Jamie; Villadangos, Jose A.
In: Nature Immunology, Vol. 17, No. 5, 05.2016, p. 531-537.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1
AU - McWilliam, Hamish E G
AU - Eckle, Sidonia B G
AU - Theodossis, Alex
AU - Liu, Ligong
AU - Chen, Zhenjun
AU - Wubben, Jacinta M
AU - Fairlie, David P
AU - Strugnell, Richard A
AU - Mintern, Justine D
AU - McCluskey, James
AU - Rossjohn, Jamie
AU - Villadangos, Jose A
PY - 2016/5
Y1 - 2016/5
N2 - The antigen-presenting molecule MR1 presents vitamin B-related antigens (VitB antigens) to mucosal-associated invariant T (MAIT) cells through an uncharacterized pathway. We show that MR1, unlike other antigen-presenting molecules, does not constitutively present self-ligands. In the steady state it accumulates in a ligand-receptive conformation within the endoplasmic reticulum. VitB antigens reach this location and form a Schiff base with MR1, triggering a molecular switch that allows MR1-VitB antigen complexes to traffic to the plasma membrane. These complexes are endocytosed with kinetics independent of the affinity of the MR1-ligand interaction and are degraded intracellularly, although some MR1 molecules acquire new ligands during passage through endosomes and recycle back to the surface. MR1 antigen presentation is characterized by a rapid off-on-off mechanism that is strictly dependent on antigen availability.
AB - The antigen-presenting molecule MR1 presents vitamin B-related antigens (VitB antigens) to mucosal-associated invariant T (MAIT) cells through an uncharacterized pathway. We show that MR1, unlike other antigen-presenting molecules, does not constitutively present self-ligands. In the steady state it accumulates in a ligand-receptive conformation within the endoplasmic reticulum. VitB antigens reach this location and form a Schiff base with MR1, triggering a molecular switch that allows MR1-VitB antigen complexes to traffic to the plasma membrane. These complexes are endocytosed with kinetics independent of the affinity of the MR1-ligand interaction and are degraded intracellularly, although some MR1 molecules acquire new ligands during passage through endosomes and recycle back to the surface. MR1 antigen presentation is characterized by a rapid off-on-off mechanism that is strictly dependent on antigen availability.
KW - antigen processing and presentation
KW - innate immune cells
UR - http://www.ncbi.nlm.nih.gov/pubmed/27043408
U2 - 10.1038/ni.3416
DO - 10.1038/ni.3416
M3 - Article
VL - 17
SP - 531
EP - 537
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 5
ER -